한빛사 논문
Jung-Hwan Lee1,2, Hae-Won Kim1,2,3
1Institute of Tissue Regeneration Engineering (ITREN), Dankook University, Cheonan, Republic of Korea
2Department of Biomaterials Science, College of Dentistry, Dankook University, Cheonan, Republic of Korea
3Department of Nanobiomedical Science & BK21 PLUS NBM Global Research Center for Regenerative Medicine, Dankook University, Cheonan, Republic of Korea
Corresponding Author: Hae-Won Kim
Abstract
Hydrogels are three-dimensional polymeric networks filled with water and mimic tissue environments. Therefore, they are considered optimal to deliver cells and engineer damaged tissues. The hydrogel networks have been significantly modified to endow biochemical functionality with adhesive ligands, growth factors, or degradable sites that are helpful to drive proper cell functions. Recently, some of the biophysical properties of hydrogels have emerged as key players in dictating cell fate. Beyond static stiffness, time-dependent stress/strain changes in the interaction with cells and the cell-mediated degradation and matrix synthesis have been demonstrated to shape cell status and tissue repair process. We highlight here the emerging biophysical properties of hydrogels that can motivate tissue engineers to design and develop hydrogels optimally for tissue regeneration.
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