한빛사 논문
Sae-Ryung Kanga, Dinh-Huy Nguyenb, Su Woong Yooa, Jung-Joon Mina,b,*
aDepartment of Nuclear Medicine, Chonnam National University Hwasun Hospital, Hwasun, Jeonnam, Korea
bDepartment of Nuclear Medicine, Chonnam National University Medical School, Hwasun, Jeonnam, Korea
*Corresponding author
Abstract
There is growing interest in the role of microorganisms in human health and disease, with evidence showing that new types of biotherapy using engineered bacterial therapeutics, including bacterial derivatives, can address specific mechanisms of disease. The complex interactions between microorganisms and metabolic/immunologic pathways underlie many diseases with unmet medical needs, suggesting that targeting these interactions may improve patient treatment. Using tools from synthetic biology and chemical engineering, non-pathogenic bacteria or bacterial products can be programmed and designed to sense and respond to environmental signals to deliver therapeutic effectors. This review describes current progress in biotherapy using live bacteria and their derivatives to achieve therapeutic benefits against various diseases.
Keywords : Bacteria-based therapy, Bacterial derivatives, Bacterial engineering, Administration, Immunotherapy, Applications
논문정보
관련 링크
연구자 키워드
연구자 ID
관련분야 연구자보기
소속기관 논문보기
관련분야 논문보기
해당논문 저자보기