한빛사 논문
Lauren Pickela, Ioan-Andrei Iliutab, James Scholeyb, York Peib, Hoon-Ki Sunga,c,*
aTranslational Medicine Program, The Hospital for Sick Children, Toronto, ON, Canada
bDivision of Nephrology, University Health Network, University of Toronto, Toronto, ON, Canada
cDepartment of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada
*Address correspondence to H-KS
Abstract
Autosomal dominant polycystic kidney disease (ADPKD) is characterized by the progressive growth of renal cysts, leading to the loss of functional nephrons. Recommendations for individuals with ADPKD to maintain a healthy diet and lifestyle are largely similar to those for the general population. However, recent evidence from preclinical models suggests that more tightly specified dietary regimens including caloric restriction, intermittent fasting, and ketogenic diets hold promise to slow disease progression, and the results of ongoing human clinical trials are eagerly awaited. These dietary interventions directly influence nutrient signalling and substrate availability in the cystic kidney, while also conferring systemic metabolic benefits. The present review focuses on the importance of local and systemic metabolism in ADPKD and summarizes current evidence for dietary interventions to slow disease progression and improve quality of life.
Keywords : diet, polycystic kidney, ADPKD, hereditary kidney disease, fasting, time-restricted feeding, time-restricted eating, ketosis, beta-hydroxybutyrate, slow progression
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