한빛사 논문
Jeong-Hyun Kim1,#, Kwoneel Kim2,#, Jeonghun Yeom3,#, Eun Lee4, Mi-Jin Kang5, Seung-Hwa Lee1, Kyunggon Kim6, So-Yeon Lee7, Sang-Bum Hong8, Dong Kyu Oh8, Kyuhong Lee9,10, Seong-Jin Choi11, Mi-Jin Yang12, Jiyeon Kim13, Soo-Jong Hong7,*
1Department of Medicine, University of Ulsan College of Medicine, Seoul, Republic of Korea
2Department of Biology, Kyung Hee University, Seoul, Republic of Korea
3Convergence Medicine Research Center, Asan Institute for Life Science, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea
4Department of Pediatrics, Chonnam National University Hospital, Chonnam National University Medical School, Gwangju, Republic of Korea
5Asan Medical Center, Humidifier Disinfectant Health Center, Seoul, Republic of Korea
6Department of Convergence Medicine, Asan Institute for Life Science, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea
7Department of Pediatrics, Childhood Asthma Atopy Center, Humidifier Disinfectant Health Center, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea
8Department of Pulmonary and Critical Care Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea
9National Center for Efficacy Evaluation of Respiratory Disease Product, Korea Institute of Toxicology, Jeollabuk-do, Republic of Korea
10Department of Human and Environmental Toxicology, University of Science & Technology, Daejeon, Republic of Korea
11Department of Inhalation Toxicology Research, Korea Institute of Toxicology, Jeollabuk-do, Republic of Korea
12Department of Pathology Research, Korea Institute of Toxicology, Jeollabuk-do, Republic of Korea
13Department of Biomedical and Pharmaceutical Sciences, Kyung Hee University, Seoul, Republic of Korea
*Correspondence : Soo-Jong Hong, Department of Pediatrics, Childhood Asthma Atopy Center, Humidifier Disinfectant Health Center, Asan Medical Center, University of Ulsan Collegeof Medicine, Seoul 05505, Republic of Korea
#These authors contributed equally to this work.
Abstract
Dear Editor,
Inhalational exposure to toxic chemicals present in humidifier disinfectant (HD), such as polyhexamethylene guanidine (PHMG), was identified as a cause of the serious lung injury,1-3 and this fatal humidifier disinfectant-associated lung injury (HDLI), as characterized by rapid progression of respiratory failure with lung fibrosis and frequent air leak syndrome with high mortality, was classified as a subcategory of interstitial lung diseases (ILDs).4, 5 However, differences in clinical progression, high mortality (44–58%), and pathology between HDLI and previously identified ILDs have aroused interest over the mechanisms of these serious lung diseases.1, 2, 6 The aim of the present study was to explore regulatory molecules and gain insight into the comprehensive biological processes associated with HDLI using integrated multispecies multi-omics of human and rat lung tissues exposed to PHMG. Study subjects and their clinical characteristics are summarized in Tables S1 and S2. The most common symptoms at admission were coughing and tachypnea in children with HDLI, and chest wall retraction and cyanosis in adult patients with HDLI.
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