한빛사 논문
Faisal Aziza,b,1,*, Imran Khana,1, Shruti Shuklac,1, Debasish Kumar Deyd, Qiu Yanb, Abhijit Chakrabortya, Hisae Yoshitomia, Seung-Kyu Hwange, Sonam Sonwale, Hoomin Leee, Yuvaraj Haldoraif, Jianbo Xiaog,h,*, Yun Suk Huhe,*, Vivek K. Bajpaii,*, Young-Kyu Hani,*
aThe Hormel Institute-University of Minnesota, Austin, MN 55912, USA
bDepartment of Biochemistry and Molecular Biology, Dalian Medical University, Liaoning Provincial Core Lab of Glycobiology and Glycoengineering, Dalian 116044, PR China
cTERI-Deakin Nanobiotechnology Centre, The Energy and Resources Institute, Gwal Pahari, Gurugram, Haryana 122003, India
dDepartment of Biotechnology, College of Engineering, Daegu University, Gyeongsan 38453, Republic of Korea
eDepartment of Biological Engineering, NanoBio High-Tech Materials Research Center, Inha University, 100 Inha-ro, Nam-gu, Incheon 22212, Republic of Korea
fDepartment of Nanoscience and Technology, Bharathiar University, Coimbatore, Tamilnadu 641046, India
gInstitute of Food Safety and Nutrition, Jinan University, Guangzhou 510632, China
hUniversity of Vigo, Nutrition and Bromatology Group, Department of Analytical Chemistry and Food Science, Faculty of Science, E32004 Ourense, Spain
iDepartment of Energy and Materials Engineering, Dongguk University-Seoul, 30 Pildong-ro 1-gil, Seoul 04620, Republic of Korea
1Authors contributed equally.
*Corresponding authors.
Abstract
Helicobacter pylori (H. pylori) is a major causative agent of chronic gastritis, gastric ulcer and gastric carcinoma. H. pylori cytotoxin associated antigen A (CagA) plays a crucial role in the development of gastric cancer. Gastric cancer is associated with glycosylation alterations in glycoproteins and glycolipids on the cell surface. H. pylori cytotoxin associated antigen A (CagA) plays a significant role in the progression of gastric cancer through post-translation modification of fucosylation to develop gastric cancer. The involvement of a variety of sugar antigens in the progression and development of gastric cancer has been investigated, including type II blood group antigens. Lewis Y (LeY) is overexpressed on the tumor cell surface either as a glycoprotein or glycolipid. LeY is a difucosylated oligosaccharide, which is catalyzed by fucosyltransferases such as FUT4 (α1,3). FUT4/LeY overexpression may serve as potential correlative biomarkers for the prognosis of gastric cancer. We discuss the various aspects of H. pylori in relation to fucosyltransferases (FUT1-FUT9) and its fucosylated Lewis antigens (LeY, LeX, LeA, and LeB) and gastric cancer. In this review, we summarize the carcinogenic effect of H. pylori CagA in association with LeY and its synthesis enzyme FUT4 in the development of gastric cancer as well as discuss its importance in the prognosis and its inhibition by combination therapy of anti-LeY antibody and celecoxib through MAPK signaling pathway preventing gastric carcinogenesis.
Keywords : Cytotoxin associated antigen A, Fucosyltransferase IV, Gastric cancer, Helicobacter pylori, Lewis Y
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