한빛사 논문
Sangyul Baik1,†, Jihyun Lee1,†, Eun Je Jeon2,3,†, Bo-yong Park4, Da Wan Kim1, Jin Ho Song1,5, Heon Joon Lee1, Seung Yeop Han2,3, Seung-Woo Cho2,6,7,* and Changhyun Pang1,8,*
1School of Chemical Engineering, Sungkyunkwan University (SKKU), 2066 Seobu-ro, Jangan-gu, Suwon 16419, Republic of Korea.
2Department of Biotechnology, Yonsei University, 50 Yonsei-ro, Seoul 03722, Republic of Korea.
3Department of Biomaterials Science and Engineering, Yonsei University, 50 Yonsei-ro, Seoul 03722, Republic of Korea.
4McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, McGill University, Montreal, Quebec H3A 2B4, Canada.
5SKKU Advanced Institute of Nanotechnology, Sungkyunkwan University (SKKU), 2066 Seobu-ro, Jangan-gu, Suwon 16419, Republic of Korea.
6Center for NanoMedicine, Institute for Basic Science (IBS), 50 Yonsei-ro, Seoul 03722, Republic of Korea.
7Graduate Program of NanoBiomedical Engineering (NanoBME), Advanced Science Institute, Yonsei University, 50 Yonsei-ro, Seoul 03722, Republic of Korea.
8Samsung Advanced Institute for Health Science & Technology (SAIHST), Sungkyunkwan University (SKKU), 2066 Seobu-ro, Jangan-gu, Suwon 16419, Republic of Korea.
*Corresponding author.
†These authors contributed equally to this work.
Abstract
Recent advances in bioinspired nano/microstructures have received attention as promising approaches with which to implement smart skin-interfacial devices for personalized health care. In situ skin diagnosis requires adaptable skin adherence and rapid capture of clinical biofluids. Here, we report a simple, all-in-one device consisting of microplungers and hydrogels that can rapidly capture biofluids and conformally attach to skin for stable, real-time monitoring of health. Inspired by the male diving beetle, the microplungers achieve repeatable, enhanced, and multidirectional adhesion to human skin in dry/wet environments, revealing the role of the cavities in these architectures. The hydrogels within the microplungers instantaneously absorb liquids from the epidermis for enhanced adhesiveness and reversibly change color for visual indication of skin pH levels. To realize advanced biomedical technologies for the diagnosis and treatment of skin, our suction-mediated device is integrated with a machine learning framework for accurate and automated colorimetric analysis of pH levels.
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