한빛사 논문
Youngsik Leea,b, Taegyu Kanga,b, Hye Rim Choa,c, Gil Ju Leed, Ok Kyu Parka,c, Sangyeon Kima,b, Bowon Leea,b, Hyun Myung Kimd, Gi Doo Chaa,b, Yoonsoo Shina,b, Wanghee Leea,b, Minjeong Kima,b, Hyunjoong Kima,b, Young Min Songd,*, Seung Hong Choia,c,* Taeghwan Hyeona,b,* and Dae-Hyeong Kima,b,e,*
aCenter for Nanoparticle Research, Institute for Basic Science (IBS), Seoul 08826, Republic of Korea
bSchool of Chemical and Biological Engineering, Institute of Chemical Processes, Seoul National University, Seoul 08826, Republic of Korea
cDepartment of Radiology, Seoul National University College of Medicine, Seoul 03080, Republic of Korea
dSchool of Electrical Engineering and Computer Science (EECS), Gwangju Institute of Science and Technology (GIST), Gwangju 61005, Republic of Korea
eDepartment of Materials Science and Engineering, Seoul National University, Seoul 08826, Republic of Korea
Y.L., T.K., H.R.C., and G.J.L. contributed equally to this work.
*To whom correspondence should be addressed.
Abstract
The low delivery efficiency of light‐responsive theranostic nanoparticles (NPs) to target tumor sites, particularly to brain tumors due to the blood–brain barrier, has been a critical issue in NP‐based cancer treatments. Furthermore, high‐energy photons that can effectively activate theranostic NPs are hardly delivered to the target region due to the strong scattering of such photons while penetrating surrounding tissues. Here, a localized delivery method of theranostic NPs and high‐energy photons to the target tumor using microneedles‐on‐bioelectronics is presented. Two types of microneedles and flexible bioelectronics are integrated and mounted on the edge of surgical forceps. Bioresorbable microneedles containing theranostic NPs deliver the NPs into target tumors (e.g., glioblastoma, pituitary adenoma). Magnetic resonance imaging can locate the NPs. Then, light‐guiding/spreading microneedles deliver high‐energy photons from bioelectronics to the NPs. The high‐energy photons activate the NPs to treat tumor tissues by photodynamic therapy and chemotherapy. The controlled thermal actuation by the bioelectronics accelerates the diffusion of chemo‐drugs. The proposed method is demonstrated with mouse tumor models in vivo.
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