한빛사 논문
Hye-Ji Kang PhD1,2,∗, Gi-Cheon Kim PhD3,4,∗, Choong-Gu Lee PhD5,∗, Sunhee Park Bs6, Garima Sharma PhD6, Ravi Verma PhD6, Sin-Hyoeg Im PhD6,7,#, Ho-Keun Kwon PhD3,4,8,#
1Advanced Green Energy and Environment Institute (AGEE), Handong Global University, Pohang 37554, Republic of Korea
2HEM, Handong-ro 558, Pohang-si, Gyungbuk, 37554, Republic of Korea
3Department of Microbiology and Immunology, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu Seoul, Seoul 03722, Korea
4Institute for Immunology and Immunological Diseases, Yonsei University College of Medicine, Seoul 03722, Korea
5Natural Product Informatics Research Center, Korea Institute of Science and Technology (KIST), Gangneung Institute of Natural Products, Gangneung, Gangwon-do, 25451, Republic of Korea
6Immunobiome, Pohang University of Science and Technology Biotech Center, Pohang 37673, Republic of Korea
7Division of Integrative Biosciences and Biotechnology (IBB), Department of Life Sciences, Pohang University of Science and Technology (POSTECH), Pohang 37673, Republic of Korea
8Brain Korea 21 PLUS Project for Medical Sciences, Yonsei University College of Medicine, Seoul 03722, Korea
∗Equally contributing first authors, #equally contributing corresponding authors
Abstract
To the Editor:
Probiotics have shown their potent immunomodulatory effects and are considered a promising alternative for the prevention and treatment of inflammatory disorders.1 However, lack of precise action mechanisms of probiotics restrained their application, especially for the treatment of non-gastrointestinal diseases such as skin allergies including atopic dermatitis and allergic contact dermatitis.2 Previously, we have shown that the combination of rationally selected 5 probiotic bacteria strains (known as IRT5) has persuasive therapeutic effects on autoimmunity.3 However, it is still unclear how oral supplementation of IRT5 modulates the immune system and eventually has therapeutic efficacy in skin allergies such as contact dermatitis and atopic dermatitis.
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