한빛사 논문
서울대학교
Dong-Yoon Kima, Miyoung Kima, Hyoun-Ee Kima,*, Young-Hag Kohb, Hae-Won Kimc, Jun-Hyeog Jangd
aSchool of Materials Science and Engineering, Seoul National University, Seoul 151-742, Republic of Korea
bDepartment of Dental Laboratory Science and Engineering, Korea University, Seoul 136-703, Republic of Korea
cDepartment of Biomaterials Science of School of Dentistry and Institute of Tissue Regeneration Engineering (ITREN), Dankook University, Cheonan 330-714, Republic of Korea
dDepartment of Biochemistry, School of Medicine, Inha University, Incheon 400-712, Republic of Korea
*Corresponding author
Abstract
Micro-arc oxidation (MAO) is commonly used to modify the surface of Ti-based medical implants with a bioactive and porous titanium oxide (TiO2) layer. This study reports a novel method of incorporating hydroxyapatite (HA) within the TiO2 layer by coupling MAO with an electrophoretic deposition (EPD) process. A HA-incorporated, porous TiO2 layer was produced successfully on the Ti substrate using the EPD-coupled MAO treatment, as confirmed by electron microscopy observations. Addition of ethanol to the electrolyte solution containing the fine HA particles was essential to reduce the level of gaseous emission on the anode, which obstructs the attachment of HA particles. In vitro cellular assays showed that the incorporation of HA significantly improved the osteoblastic activity on the coating layer.
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