한빛사 논문
가톨릭대학교
Sung Hun Kim, MD,1 Eun Suk Cha, MD,1* Hyeon Sook Kim, MD,1 Bong Joo Kang, MD,1 Jae Jeong Choi, MD,1 Ji Han Jung, MD,2 Yong Gyu Park, PhD,3 and Young Jin Suh, MD4
1Department of Radiology, The Catholic University of Korea, Seoul, Republic of Korea.
2Department of Hospital Pathology, The Catholic University of Korea, Seoul, Republic of Korea.
3Department of Biostatistics, The Catholic University of Korea, Seoul, Republic of Korea.
4Department of Surgery, The Catholic University of Korea, Seoul, Re-public of Korea.
*Address reprint requests to: E.S.C
Abstract
Purpose
To evaluate the role of diffusion‐weighted imaging (DWI) in the detection of breast cancers, and to correlate the apparent diffusion coefficient (ADC) value with prognostic factors.
Materials and Methods
Sixty‐seven women with invasive cancer underwent breast MRI. Histological specimens were analyzed for tumor size and grade, and expression of estrogen receptors (ER), progesterone receptors, c‐erbB‐2, p53, Ki‐67, and epidermal growth factor receptors. The computed mean ADC values of breast cancer and normal breast parenchyma were compared. Relationships between the ADC values and prognostic factors were determined using Wilcoxon signed rank test and Kruskal‐Wallis test.
Results
DWI detected breast cancer as a hyperintense area in 62 patients (92.5 %). A statistically significant difference in the mean ADC values of breast cancer (1.09 ± 0.27 × 10−5 mm2/s) and normal parenchyma (1.59 ± 0.27 × 10−5 mm2/s) was detected (P < 0.0001). There were no correlations between the ADC value and prognostic factors. However, the median ADC value was lower in the ER‐positive group than the ER negative group, and this difference was marginally significant (1.09 × 10−5 mm2/s versus 1.15 × 10−5 mm2/s, P = 0.053).
Conclusion
The ADC value was a helpful parameter in detecting malignant breast tumors, but ADC value could not predict patient prognosis.
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