한빛사 논문
Hyogeun Shin1,2, Sohyeon Jeong1,2, Ju-Hyun Lee3, Woong Sun3, Nakwon Choi1,2,4,* & Il-Joo Cho1,2,5,6,*
1Center for BioMicrosystems, Brain Science Institute, Korea Institute of Science and Technology (KIST), Seoul, Republic of Korea.
2Division of Bio-Medical Science and Technology, KIST School, Korea University of Science and Technology (UST), Seoul, Republic of Korea.
3Department of Anatomy, Korea University College of Medicine, Seoul, Republic of Korea. 4KU-KIST Graduate School of Converging Science and Technology, Korea University Seoul, Republic of Korea.
5School of Electrical and Electronics Engineering, Yonsei University, Seoul, Republic of Korea.
6Yonsei-KIST Convergence Research Institute, Yonsei University, Seoul, Republic of Korea.
*Corresponding author
Abstract
Investigation of neural circuit dynamics is crucial for deciphering the functional connections among regions of the brain and understanding the mechanism of brain dysfunction. Despite the advancements of neural circuit models in vitro, technologies for both precisely monitoring and modulating neural activities within three-dimensional (3D) neural circuit models have yet to be developed. Specifically, no existing 3D microelectrode arrays (MEAs) have integrated capabilities to stimulate surrounding neurons and to monitor the temporal evolution of the formation of a neural network in real time. Herein, we present a 3D high-density multifunctional MEA with optical stimulation and drug delivery for investigating neural circuit dynamics within engineered 3D neural tissues. We demonstrate precise measurements of synaptic latencies in 3D neural networks. We expect our 3D multifunctional MEA to open up opportunities for studies of neural circuits through precise, in vitro investigations of neural circuit dynamics with 3D brain models.
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