Hye Ryun Woo and Eric J. Richards1
Department of Biology, Washington University in St. Louis, St. Louis,
Missouri 63130, USA
Among the persistent mysteries in epigenetics are the
criteriaby which specific regions of the genome are chosen for
depositionof distinguishing chromatin marks. Once a particular
regionis modified, will the newly acquired epigenetic state
spillonto neighboring regions of the genome or be confined to
tidypatches? The report by Henderson and Jacobsen in the the
previousissue of Genes & Development (1597-1606)
addressesthese questions while providing insight into the utility
ofDNA methylation for a eukaryotic genome.
[Keywords: Epigenetics; DNA methylation; siRNA; gene silencing]1
Article is online at http://www.genesdev.org/cgi/doi/10.1101/gad.1694608.