한빛사 논문
Namil Lee†,a,b, Soonkyu Hwang,†,a,b, Woori Kima,b, Yongjae Leea,b, Ji Hun Kima,b, Suhyung Choa,b, Hyun Uk Kimc, Yeo Joon Yoon*,d, Min-Kyu Oh*,e, Bernhard O. Palsson*,f,g,h and Byung-Kwan Cho*,a,b,h
aDepartment of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon 34141, Republic of Korea
bInnovative Biomaterials Centre, KI for the BioCentury, Korea Advanced Institute of Science and Technology, Daejeon 34141, Republic of Korea
cDepartment of Chemical and Biomolecular Engineering, Korea Advanced Institute of Science and Technology, Daejeon 34141, Republic of Korea
dCollege of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea
eDepartment of Chemical and Biological Engineering, Korea University, Seoul 02841, Republic of Korea
fDepartment of Bioengineering, University of California San Diego, La Jolla, CA, USA
gDepartment of Pediatrics, University of California San Diego, La Jolla, CA, USA
hNovo Nordisk Foundation Centre for Biosustainability, Technical University of Denmark, Lyngby, Denmark
*Corresponding authors
†These authors contributed equally to this work.
Abstract
Over the last few decades, Streptomyces have been extensively investigated for their ability to produce diverse bioactive secondary metabolites. Recent advances in Streptomyces research have been largely supported by improvements in high-throughput technology ‘omics’. From genomics, numerous secondary metabolite biosynthetic gene clusters were predicted, increasing their genomic potential for novel bioactive compound discovery. Additional omics, including transcriptomics, translatomics, interactomics, proteomics and metabolomics, have been applied to obtain a system-level understanding spanning entire bioprocesses of Streptomyces, revealing highly interconnected and multi-layered regulatory networks for secondary metabolism. The comprehensive understanding derived from this systematic information accelerates the rational engineering of Streptomyces to enhance secondary metabolite production, integrated with the exploitation of the highly efficient ‘Design–Build–Test–Learn’ cycle in synthetic biology. In this review, we describe the current status of omics applications in Streptomyces research to better understand the organism and exploit its genetic potential for higher production of valuable secondary metabolites and novel secondary metabolite discovery.
논문정보
관련 링크
연구자 키워드
연구자 ID
관련분야 연구자보기
관련분야 논문보기