한빛사 논문
Miae Wona,1, Mingle Lia,1, Hyeong Seok Kima,1, Pai Liua,1, Seyoung Kooa,1, Subin Sona, Jae Hong Seob,*, Jong Seung Kima,*
aDepartment of Chemistry, Korea University, Seoul 02841, Republic of Korea
bDivision of Medical Oncology, Department of Internal Medicine, Korea University College of Medicine, Korea University, Seoul 08308, Republic of Korea
1These authors contributed equally.
*Corresponding author
Abstract
Fluorescence imaging is an essential and interdisciplinary optical technique that uses light signals from molecules, cells, and living organisms to visualize dynamic biological processes. Moreover, with recent remarkable breakthroughs in the development of chemical mechanisms (e.g., aggregation-induced emission, donor-π-acceptor electron manipulation for near IR region II fluorescence emission, multi-photon absorption and molecular rotor), nanofabrication technologies, and newly discovered biomarkers, the opportunities to generate multifunctional bespoke probes for the rapid analysis and highly accurate diagnosis of early-stage cancers have increased. In this article, we mainly review the recent advances in some representative small molecule-based fluorescence probes and their nanocomposites with an emphasis on the design principles to enhance the recognition selectivity/sensitivity, improve the signal-to-background ratio, amplify the fluorescence emission brightness, and optimize the tissue penetration depth. Furthermore, we highlight the current challenges and further opportunities from the viewpoint of the practical applications of this emerging field.
논문정보
관련 링크
연구자 키워드
연구자 ID
관련분야 연구자보기
소속기관 논문보기
관련분야 논문보기