한빛사 논문
Jung-Hwan Leea,b,c,d,f,1, Prakash Parthibana,1, Guang-Zhen Jina,b,c,f, Jonathan C. Knowlesa,c,e, Hae-Won Kima,b,c,d,f,*
aInstitute of Tissue Regeneration Engineering (ITREN), Dankook University, Cheonan 31116, Republic of Korea
bUCL Eastman-Korea Dental Medicine Innovation Centre, Dankook University, Cheonan 31116, Republic of Korea
cDepartment of Nanobiomedical Science & BK21 NBM Global Research Center for Regenerative Medicine, Dankook University, Cheonan 31116, Republic of Korea
dDepartment of Biomaterials Science, School of Dentistry, Dankook University, Cheonan 31116, Republic of Korea
eUCL Eastman Dental Institute, 256 Grays Inn Road, London WC1X 8LD, United Kingdom
fCell & Matter Institute, Dankook University, Cheonan 31116, Republic of Korea
1Both authors equally contributed to this work.
*Corresponding author
Abstract
Enabling angiogenesis is critical for the success of tissue repair therapies and the fate of tissue-engineered constructs. Although many biochemical signaling molecules have been used, their biological functions in vivo are known to be limited, mainly due to their short lifetime and poor activity. Matrices (or engineered biomaterials), beyond the biochemical signals, play pivotal roles in stimulating angiogenic processes. Here we discuss the proangiogenic effort taken to repair and regenerate various tissues including skin, bone, muscle and nerve, focusing on the roles of engineered matrices. This includes the design of pore structure and physico-chemical properties (nanotopology, stiffness, chemistry and degradability), the tailoring of matrices for proper presentation of growth factors and their crosstalks with adhesion ligands, the controlled and sustained delivery of angiogenic molecules and metallic ions, and the engineering of cells and construction of prevascularized tissues. Collectively, the materials-driven strategies are envisaged to tune the cell and tissue microenvironments where angiogenic events can be significantly favored through the matrix cues and properly presented or delivered signaling molecules and cells.
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