한빛사 논문
Yuce Lia,b, Jun Xieb, Wooram Uma, Dong Gil Youa, Seunglee Kwona, Lianbin Zhangb, Jintao Zhub,* and Jae Hyung Parka,c,d,*
aSchool of Chemical Engineering, College of Engineering, Sungkyunkwan University (SKKU), Suwon 16419, Republic of Korea
bKey Laboratory of Material Chemistry for Energy Conversion and Storage (HUST) of Ministry of Education, School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology (HUST), Wuhan 430074, China
cDepartment of Health Sciences and Technology, Samsung Advanced Institute for Health Sciences & Technology (SAIHST), Sungkyunkwan University, Suwon 16419, Republic of Korea
dBiomedical Institute for Convergence at SKKU (BICS), Sungkyunkwan University, Seobu-ro 2066, Jangan-gu, Suwon 16419, Republic of Kore
*To whom correspondence should be addressed.
Y.L. and J.X. contributed equally to this work
Abstract
Immunotherapy (e.g., cancer vaccines and checkpoint blockades), harnessing the host immune system to recognize and eradicate tumors, has emerged as one of the most potent cancer therapies. The clinical applications of cancer immunotherapies, however, have been limited by their low response rates and immune‐related adverse effects. In recent years, sono/photodynamic nanomedicines (SPNs) have received increasing attention for cancer therapy since they have been reported to mediate enhanced immunotherapy by generating reactive oxygen species under site‐specific exposure to exogenous energy sources. In particular, SPNs are capable of eliciting immunogenic cancer cell death, leading to the release of tumor‐associated antigens and damage‐associated molecular patterns. This allows for the maturation of antigen‐presenting cells, thus eliminating disseminated or metastatic tumor cells by cytotoxic CD8+ T cells. Such immunostimulatory features of SPNs provide opportunities to enhance therapeutic potential by amplifying anticancer immunity when combined with conventional immunotherapeutics, including immune checkpoint inhibitors. This review elaborates on the recent strategies and efforts undertaken by researchers to enhance SPN‐elicited cancer immunotherapy. The challenging issues and opportunities for SPNs in the activation of innate or adaptive immune responses and regulation of the tumor immunosuppressive microenvironment are also described.
Keywords: immunogenic cell death, immunotherapy, nanomedicine, photodynamic therapy, sonodynamic therapy
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