한빛사 논문
Dong-Sic Choi1,*, Dae-Kyum Kim,1,*, Seng Jin Choi1,*, Jaewook Lee1, Jun-Pyo Choi1, Sangchul Rho2, Sang-Hyun Park3, Yoon-Keun Kim1, Daehee Hwang2,4** and Yong Song Gho1
1Department of Life Science and Division of Molecular and Life Sciences, Pohang University of Science and Technology, Pohang, Republic of Korea
2School of Interdisciplinary Bioscience and Bioengineering, Pohang University of Science and Technology, Pohang, Republic of Korea
3Department of Biological Sciences, Seoul National University, Seoul, Republic of Korea
4Department of Chemical Engineering, Pohang University of Science and Technology, Pohang, Republic of Korea
*These authors contributed equally to this work.
**Additional corresponding author: Professor Daehee Hwang
Correspondence: Professor Yong Song Gho, Ph.D.
Abstract
Pseudomonas aeruginosa, an opportunistic human bacterial pathogen, constitutively secretes outer membrane vesicles (OMVs) into the extracellular milieu. Although recent progress has revealed that OMVs are essential for pathogenesis of P. aeruginosa, their proteins have not been comprehensively analyzed so far. In this study, we identified 338 vesicular proteins with high confidence by five separate LC‐MS/MS analyses. This global proteome profile provides a basis for future studies to elucidate the pathological functions of OMVs from P. aeruginosa.
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