한빛사 논문
SangJoon Lee1, Rudragouda Channappanavar2,3, Thirumala-Devi Kanneganti1,*
1Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA
2Department of Microbiology, Immunology, & Biochemistry, University of Tennessee Health Sciences Center, Memphis, TN, 38163, USA
3Department of Acute and Tertiary Care, University of Tennessee Health Sciences Center, Memphis, TN, 38163, USA
*Corresponding author
Abstract
The innate immune system acts as the first line of defense against pathogens, including coronaviruses. SARS-CoV and MERS-CoV are epidemic zoonotic coronaviruses that emerged at the beginning of the 21st century. The recently emerged virus SARS-CoV-2 is a novel strain of coronavirus that has caused the COVID-19 pandemic. Scientific advancements made by studying the SARS-CoV and MERS-CoV outbreaks have provided a foundation for understanding pathogenesis and innate immunity against SARS-CoV-2. In this review, we focus on our present understanding of innate immune responses, inflammasome activation, inflammatory cell death pathways, and cytokine secretion during SARS-CoV, MERS-CoV, and SARS-CoV-2 infection. We also discuss how the pathogenesis of these viruses influences these biological processes.
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