A successful identification of DNA–DNA recognition, based on the waveguide effect of a 1D hybrid prismatic hexagon crystal interfacing of DNA with an organic semiconductor is achieved. This bio‐hybrid 1D crystal simultaneously discerns the complementary case at its one end against a 1‐mer mismatch in 27‐mer nucleic acid sequence at the other end. The loss coefficient value of this waveguide is estimated to be 0.159 µm−1 for the perfect match, which is a stark discrepancy compared to 0.244 µm−1 for the 1‐mer mismatch, implying waveguide performance with a higher efficiency. These results demonstrate successfully that multiple biological interactions can be realized by the optical waveguide of the single 1D bio‐hybrid‐crystal and will push this class of materials into bio‐related applications.
Keywords : 1D waveguides, bio-photonics, DNA-hybrid assemblies, multiple remote sensing