한빛사 논문
Hankyul Kwak1,19, Wuhyun Koh2,3,4,19, Sangwoo Kim1, Kiyeong Song1, Jeong-Im Shin2,3, Jung Moo Lee3,4,5, Elliot H. Lee1, Jin Young Bae6, Go Eun Ha1, Ju-Eun Oh7, Yongmin Mason Park2,3,4, Sunpil Kim4,5, Jiesi Feng8, Seung Eun Lee9, Ji Won Choi10, Ki Hun Kim11, Yoo Sung Kim12, Junsung Woo3, Dongsu Lee1, Taehwang Son13, Soon Woo Kwon14, Ki Duk Park2,10,15, Bo-Eun Yoon12, Jaeick Lee11, Yulong Li8,16,17,Hyunbeom Lee7, Yong Chul Bae6, C. Justin Lee2,3,4,*, Eunji Cheong1,18,20,*
1Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University, Seoul 03722, South Korea
2Division of Bio-Medical Science &Technology, KIST School, Korea University of Science and Technology, Seoul 02792, South Korea
3Center for Glia-Neuron Interaction, Korea Institute of Science and Technology, Seoul 02792, South Korea
4Center for Cognition and Sociality, Institute for Basic Science, Daejeon 34126, South Korea
5KU-KIST Graduate School of Converging Science and Technology, Korea University, Seoul 02841, South Korea
6Department of Anatomy and Neurobiology, School of Dentistry, Kyungpook National University, Daegu 41566, South Korea
7Molecular Recognition Research Center, Korea Institute of Science and Technology, Seoul 02792, South Korea
8State Key Laboratory of Membrane Biology, Peking University School of Life Sciences, Beijing 100871, China
9Virus Facility, Research Animal Resource Center, Korea Institute of Science and Technology, Seoul 02792, South Korea
10Convergence Research Center for Diagnosis, Treatment and Care System of Dementia, Korea Institute of Science and Technology, Seoul 02792, South Korea
11Doping Control Center, Korea Institute of Science and Technology, Seoul 02792, South Korea
12Department of Molecular Biology, College of Natural Science, Dankook University, Cheonan 31116, South Korea
13School of Electrical and Electronic Engineering, Yonsei University, Seoul 03722, South Korea
14Radiation Medicine Clinical Research Division, Korea Institute of Radiological and Medical Sciences, Seoul, South Korea
15KHU-KIST Department of Converging Science and Technology, Kyung Hee University, Seoul 02447, South Korea
16Peking-Tsinghua Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing 100871, China
17PKU-IDG/McGovern Institute for Brain Research, Beijing 100871, China
18POSTECH Biotech Center, POSTECH, Pohang, South Korea
19These authors contributed equally
20Lead Contact
*Corresponding author
Abstract
Sensory discrimination is essential for survival. However, how sensory information is finely controlled in the brain is not well defined. Here, we show that astrocytes control tactile acuity via tonic inhibition in the thalamus. Mechanistically, diamine oxidase (DAO) and the subsequent aldehyde dehydrogenase 1a1 (Aldh1a1) convert putrescine into GABA, which is released via Best1. The GABA from astrocytes inhibits synaptically evoked firing at the lemniscal synapses to fine-tune the dynamic range of the stimulation-response relationship, the precision of spike timing, and tactile discrimination. Our findings reveal a novel role of astrocytes in the control of sensory acuity through tonic GABA release.
논문정보
TOP52020년 후보
관련 링크
연구자 키워드
연구자 ID
관련분야 연구자보기
소속기관 논문보기
관련분야 논문보기