한빛사 논문
Fu-Shi Quan1,*, Ilaria Rubino2,*, Su-Hwa Lee3, Brendan Koch2 & Hyo-Jick Choi2
1Department of Medical Zoology, Kyung Hee University School of Medicine, Seoul, 130-701, Korea. 2Department of Chemical and Materials Engineering, University of Alberta, Edmonton, AB T6G 1H9, Canada. 3Department of Biomedical Science, Graduate School, Kyung Hee University, Seoul, 130-701, Korea. *These authors contributed equally to this work.
Correspondence and requests for materials should be addressed to H.J.C.
Abstract
Aerosolized pathogens are a leading cause of respiratory infection and transmission. Currently used protective measures pose potential risk of primary/secondary infection and transmission. Here, we report the development of a universal, reusable virus deactivation system by functionalization of the main fibrous filtration unit of surgical mask with sodium chloride salt. The salt coating on the fiber surface dissolves upon exposure to virus aerosols and recrystallizes during drying, destroying the pathogens. When tested with tightly sealed sides, salt-coated filters showed remarkably higher filtration efficiency than conventional mask filtration layer, and 100% survival rate was observed in mice infected with virus penetrated through salt-coated filters. Viruses captured on salt-coated filters exhibited rapid infectivity loss compared to gradual decrease on bare filters. Salt-coated filters proved highly effective in deactivating influenza viruses regardless of subtypes and following storage in harsh environmental conditions. Our results can be applied in obtaining a broad-spectrum, airborne pathogen prevention device in preparation for epidemic and pandemic of respiratory diseases.
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