한빛사 논문
경북대학교
Keon-Yeop Kim,1* Dong-Sun Kim,2* Sung-Kook Lee,1 In-Kyu Lee,3 Jung-Ho Kang,4 Yoon-Seok Chang,4 David R. Jacobs, Jr.,5,6 Michael Steffes,7 and Duk-Hee Lee1,#
1Department of Preventative Medicine, 2Department of Anatomy, 3Department of Endocrinology, School of Medicine, Kyungpook National University, Daegu, Korea; 4School of Environmental Science and Engineering, POSTECH, Pohang, Korea; 5Department of Laboratory Medicine and Pathology, School of Medicine, University of Minnesota, Minneapolis, Minnesota, USA; 6Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis, Minnesota, USA; 7Department of Nutrition, University of Oslo, Oslo, Norway
*These authors contributed equally to this work.
#Corresponding author
Abstract
Background
Global DNA methylation levels have been reported to be inversely associated with blood levels of persistent organic pollutants (POPs), xenobiotics that accumulate in adipose tissue. Whether these associations extend to a population with much lower concentrations of POPs is not known.
Objectives
This study was performed to examine whether low-dose exposure to POPs was associated with global DNA hypomethylation in Koreans.
Methods
The amount of global DNA hypomethylation was estimated by the percent 5-methyl-cytosine (%5-mC) in Alu and LINE-1 assays in 86 apparently healthy Koreans. Among various POPs, organochlorine (OC) pesticides, polychlorinated biphenyls (PCBs), and polybrominated diphenylethers (PBDEs) were measured.
Results
Most OC pesticides were inversely and significantly associated with %5-mC in the Alu assay, with correlation coefficients in the range −0.2 to −0.3 after adjusting for age, sex, body mass index, smoking, and alcohol. The strongest OC pesticide associations with %5-mC in the Alu assay were observed with oxychlordane, trans-nonachlor, and p,p′-dichlorodiphenyldichloroethylene. The correlation coefficient of age with %5-mC in the Alu assay was −0.24, similar to correlations of OC pesticides with %5-mC in the Alu assay. Most PCBs and PBDEs showed nonsignificant inverse trends with %5-mC in the Alu assay, but for some PCBs the U-shaped association was significant. On the other hand, POPs were not associated with %5-mC in the LINE-1 assay.
Conclusions
We found that low-dose exposure to POPs, in particular OC pesticides, was associated with global DNA hypomethylation in apparently healthy Koreans.
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