한빛사 논문
Tae-Min Kim1, In Seok Yang2, Byung-Joon Seung3, Sejoon Lee4, Dohyun Kim5, Yoo-Jin Ha2, Mi-kyoung Seo2, Ka-Kyung Kim2, Hyun Seok Kim6, Jae-Ho Cheong2, Jung-Hyang Sur3, Hojung Nam5 & Sangwoo Kim2,*
1Department of Medical Informatics and Cancer Research Institute, College of Medicine, The Catholic University of Korea, Seoul 06591, South Korea.
2Department of Biomedical Systems Informatics and Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of Medicine, Seoul 03722, South Korea.
3Department of Veterinary Pathology, Small Animal Tumor Diagnostic Center, College of Veterinary Medicine, Konkuk University, Seoul 05029, South Korea.
4Department of Pathology and Translational Medicine, Seoul National University Bundang Hospital, Seongnam 13620, South Korea.
5School of Electrical Engineering and Computer Science, Gwangju Institute of Science and Technology (GIST), Gwangju 61005, South Korea.
6Severance Biomedical Science Institute, Yonsei University College of Medicine, Seoul 03722, South Korea.
*Corresponding author
Abstract
Genomic and precision medicine research has afforded notable advances in human cancer treatment, yet applicability to other species remains uncertain. Through whole-exome and transcriptome analyses of 191 spontaneous canine mammary tumors (CMTs) that exhibit the archetypal features of human breast cancers, we found a striking resemblance of genomic characteristics including frequent PIK3CA mutations (43.1%), aberrations of the PI3K-Akt pathway (61.7%), and key genes involved in cancer initiation and progression. We also identified three gene expression-based CMT subtypes, one of which segregated with basal-like human breast cancer subtypes with activated epithelial-to-mesenchymal transition, low claudin expression, and unfavorable disease prognosis. A relative lack of ERBB2 amplification and Her2-enrichment subtype in CMT denoted species-specific molecular mechanisms. Taken together, our results elucidate cross-species oncogenic signatures for a better understanding of universal and context-dependent mechanisms in breast cancer development and provide a basis for precision diagnostics and therapeutics for domestic dogs.
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TOP52020년 후보
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