한빛사 논문
Ga Eun Nam1, Wonsock Kim1, Kyungdo Han2,3, Chung-woo Lee1, Yeongkeun Kwon1, Byoungduck Han1, Seokwon Park1, Joo-Hyun Park1, Yang-Hyun Kim1, Do-Hoon Kim1, Seon Mee Kim1, Youn Seon Choi1, Kyung Hwan Cho1 and Yong Gyu Park2⇑
1Department of Family Medicine, Korea University College of Medicine, Seoul, Republic of Korea
2Department of Biostatistics, The Catholic University of Korea, Seoul, Republic of Korea
3Department of Statistics and Actuarial Science, Soongsil University, Seoul, Republic of Korea
⇑Corresponding author: Yong Gyu Park
G.E.N. and W.K. contributed equally to this work.
Abstract
OBJECTIVE
Obesity and type 2 diabetes are risk factors for cardiovascular diseases and mortality, and they commonly result in weight variabilities. We aimed to investigate the association between body weight variability and risk of major cardiovascular outcomes and mortality in individuals with type 2 diabetes using large-scale, nationwide cohort data on the Korean population.
RESEARCH DESIGN AND METHODS
We enrolled 624,237 individuals with type 2 diabetes who underwent health examinations provided by the Korean National Health Insurance System between 2009 and 2010, with three or more body weight measurements within 5 years since enrollment and followed up until the end of 2017. We assessed body weight variability using four indices, including variability independent of the mean (VIM). A multivariate-adjusted Cox proportional hazards regression analysis was performed.
RESULTS
During the follow-up, 15,832, 25,038, and 44,716 cases of myocardial infarction (MI), stroke, and all-cause mortality, respectively, were recorded. Body weight variability was associated with increased risks of major cardiovascular outcomes after adjusting for confounding variables. Compared with the hazard ratios (HRs) of the lowest quartile group, the HRs (95% CIs) of the highest quartile group of VIM for body weight were 1.15 (1.10–1.20), 1.22 (1.18–1.26), and 1.58 (1.53–1.62) for MI, stroke, and all-cause mortality, respectively.
CONCLUSIONS
Body weight variability was associated with increased risks of MI, stroke, and all-cause mortality in type 2 diabetes patients and may be a predictor of cardiovascular outcomes in such patients. Appropriate interventions to maintain stable weight could positively influence health outcomes in type 2 diabetes patients.
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