한빛사 논문
Pil-Ryung Cha1*, Hyung-Seop Han2*, Gui-Fu Yang2, Yu-Chan Kim2, Ki-Ha Hong3, Seung-Cheol Lee4, Jae-Young Jung5, Jae-Pyeong Ahn5, Young-Yul Kim6, Sung-Youn Cho7, Ji Young Byun8, Kang-Sik Lee9, Seok-Jo Yang10 & Hyun-Kwang Seok2,#
1School of Advanced Materials Engineering, Kookmin University, Seoul 136-702, South Korea, 2Center for Biomaterials, Korea Institute of Science & Technology, Seoul 136-650, South Korea, 3Department of Materials Science and Engineering, Hanbat National University, Daejeon, 305-719, South Korea, 4Electronic Materials Research Center, Korea Institute of Science & Technology, Seoul 136-650, South Korea, 5Advanced Analysis Center, Korea Institute of Science & Technology, Seoul 136-650, South Korea, 6Department of Orthopedics, St. Mary’s Hospital, The Catholic University of Korea, Daejeon 301-723, South Korea, 7R&D Center, U&I Corporation, Uijongbu 480-050, South Korea, 8Center for Materials Architecturing, Korea Institute of Science and Technology, Seoul 136-650, Republic of Korea, 9Department of Orthopedic Surgery, Asan Medical Center, Seoul 138-736, Korea, 10Department of Mechatronics Engineering, Chungnam National University, Daejeon 305-764, South Korea.
*These authors contributed equally to this work.
#Corresponding author
Abstract
Crystalline Mg-based alloys with a distinct reduction in hydrogen evolution were prepared through both electrochemical and microstructural engineering of the constituent phases. The addition of Zn to Mg-Ca alloy modified the corrosion potentials of two constituent phases (Mg + Mg2Ca), which prevented the formation of a galvanic circuit and achieved a comparable corrosion rate to high purity Mg. Furthermore, effective grain refinement induced by the extrusion allowed the achievement of much lower corrosion rate than high purity Mg. Animal studies confirmed the large reduction in hydrogen evolution and revealed good tissue compatibility with increased bone deposition around the newly developed Mg alloy implants. Thus, high strength Mg-Ca-Zn alloys with medically acceptable corrosion rate were developed and showed great potential for use in a new generation of biodegradable implants.
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