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Proteomics in gram-negative bacterial outer membrane vesicles
Eun-Young Lee 1, Dong-Sic Choi 1, Kwang-Pyo Kim 2, Yong Song Gho 1 *

1Department of Life Science and Division of Molecular and Life Sciences, Pohang University of Science and Technology, Pohang, Republic of Korea
2Institute of Biomedical Science and Technology, Department of Molecular Biotechnology, Konkuk University, Seoul, Republic of Korea
*Correspondence to Yong Song Gho, Department of Life Science, Division of Molecular and Life Sciences, Pohang University of Science and Technology, San31 Hyojadong, Pohang, Kyungbuk 790-784, Republic of Korea.

Funded by:
- National R&D Program for Cancer Control, Ministry of Health & Welfare, Republic of Korea; Grant Number: 0320380-2
- Korea Basic Science Institute K-MeP; Grant Number: T27021
- Korea Science and Engineering Foundation (KOSEF) (MOST); Grant Number: R15-2004-033-05001-0
- Brain Korea 21 fellowship

outer membrane vesicles, gram-negative bacteria, communicasomes, antibiotics, proteomics, vaccines


Gram-negative bacteria constitutively secrete outer membrane vesicles (OMVs) into the extracellular milieu. Recent research in this area has revealed that OMVs may act as intercellular communicasomes in polyspecies communities by enhancing bacterial survival and pathogenesis in hosts. However, the mechanisms of vesicle formation and the pathophysiological roles of OMVs have not been clearly defined. While it is obvious that mass spectrometry-based proteomics offers great opportunities for improving our knowledge of bacterial OMVs, limited proteomic data are available for OMVs. The present review aims to give an overview of the previous biochemical, biological, and proteomic studies in the emerging field of bacterial OMVs, and to give future directions for high-throughput and comparative proteomic studies of OMVs that originate from diverse Gram-negative bacteria under various environmental conditions. This article will hopefully stimulate further efforts to construct a comprehensive proteome database of bacterial OMVs that will help us not only to elucidate the biogenesis and functions of OMVs but also to develop diagnostic tools, vaccines, and antibiotics effective against pathogenic bacteria. © 2008 Wiley Periodicals, Inc., Mass Spec Rev
Received: 12 December 2007; Accepted: 28 February 2008

Digital Object Identifier (DOI)
10.1002/mas.20175  About DOI

- 형식: Review Paper
- 게재일: 2008년 04월 (BRIC 등록일 2016-03-16)
- 연구진: 국내연구진태극기
- 피인용횟수: 120회 이상 인용된 논문
Dot/Icm 제 4 유형 커플링 단백질 복합체의 선택적 이펙터 단백질 인식[Nat. Commun.]
발표: 김현민 (KAIST)
일자: 2020년 9월 29일 (화) 오후 02시 (한국시간)
언어: 한국어
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