한빛사 논문
Abstract
Van Thi Lo1,2, Sun‐Woo Yoon1,2, Ji Yeong Noh3, Youngji Kim1, Yong Gun Choi4, Dae Gwin Jeong1,2,*, Hye Kwon Kim3,*
1Infectious Disease Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, Korea
2Bio-Analytical Science Division, Korea University of Science and Technology (UST), Daejeon, Korea
3Department of Microbiology, College of Natural Sciences, Chungbuk National University, Cheongju, Korea
4The Korean Institute of Biospeleology, Daejeon, Korea
Van Thi Lo, Sun‐Woo Yoon and Ji Yeong Noh contributed equally.
*Correspondence :
Hye Kwon Kim, Department of Microbiology, College of Natural Sciences, Chungbuk National University, Cheongju, Korea.
Dae Gwin Jeong, Infectious Disease Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, Korea
Abstract
Bats harbour diverse coronaviruses (CoVs), some of which are associated with zoonotic infections, as well as inter‐species transmission. In this study, a total of 512 bat faecal samples from the bat habitats at different geographical locations in South Korea were investigated between 2016 and 2019. Seventy‐eight samples were positive for coronaviruses (15.2%), comprising 68 alphacoronaviruses (13.3%) and 10 betacoronaviruses (2.0%). The positive rates tended to increase during the awakening (April) period. Notably, betacoronaviruses were only found in the site where Rhinolophus ferrumequinum was the major species of bats, and were related to SARS‐ and MERS‐related CoVs identified in China and South Korea, respectively. No betacoronaviruses were closely related to SARS‐CoV‐2 in this study. Alphacoronaviruses were detected in the sites where Hypsugo alaschanicus , Miniopterus fuliginosus , Miniopterus schreibersii , Rhinolophus ferrumequinum , Myotis bombinus , Myotis macrodactylus and Myotis petax were found to be the major bat species. Furthermore, alphacoronaviruses had higher genetic diversity than betacoronaviruses and had a wider distribution in Korea. Considering that different bat species are co‐roosting in crowded conditions in the same habitat, the diverse coronaviruses in Korean bats are likely to undergo cross‐species transmission events due to the richness in host species. Therefore, continuous monitoring should be performed, especially at the awakening time of the hibernating bats in the habitats where diverse bat species co‐roost, to better understand the evolution of coronaviruses in bats.
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