한빛사 논문
Byung-Chul Lee1,*,†, Jin Young Lee1,*,‡, Juhee Kim2, Je Min Yoo2,§, Insung Kang1, Jae-Jun Kim1, Nari Shin1, Dong Jin Kim3, Soon Won Choi1, Donghoon Kim4, Byung Hee Hong2,4,5,|| and Kyung-Sun Kang1,||
1Adult Stem Cell Research Center and Research Institute for Veterinary Science, College of Veterinary Medicine, Seoul National University, Seoul 08826, Republic of Korea.
2Department of Chemistry, College of Natural Sciences, Seoul National University, Seoul 08826, Republic of Korea.
3Program in Nano Science and Technology, Graduate School of Convergence Science and Technology, Seoul National University, Seoul 08826, Republic of Korea.
4Biographene Inc., Advanced Institute of Convergence Technology, Suwon 16229, Republic of Korea.
5Graphene Research Center, Advanced Institute of Convergence Technology, Seoul National University, Suwon 16229, Republic of Korea.
||Corresponding author.
*These authors contributed equally to this work.
†Present address: Translational Stem Cell Biology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA.
‡Present address: Department of Medicine, Cardiovascular Research Institute, UCSF, San Francisco, CA 94143, USA.
§Present address: Biographene Inc., 555 W 5th St 35th Floor, Los Angeles, CA 90013, USA.
Abstract
While graphene and its derivatives have been suggested as a potential nanomedicine in several biomimetic models, their specific roles in immunological disorders still remain elusive. Graphene quantum dots (GQDs) may be suitable for treating intestinal bowel diseases (IBDs) because of their low toxicity in vivo and ease of clearance. Here, GQDs are intraperitoneally injected to dextran sulfate sodium (DSS)–induced chronic and acute colitis model, and its efficacy has been confirmed. In particular, GQDs effectively prevent tissue degeneration and ameliorate intestinal inflammation by inhibiting TH1/TH17 polarization. Moreover, GQDs switch the polarization of macrophages from classically activated M1 to M2 and enhance intestinal infiltration of regulatory T cells (Tregs). Therefore, GQDs effectively attenuate excessive inflammation by regulating immune cells, indicating that they can be used as promising alternative therapeutic agents for the treatment of autoimmune disorders, including IBDs.
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