한빛사 논문
Kim MS1, Park BC2, Kim YJ3, Lee JH4, Koo TM5, Ko MJ5, Kim YK1,*
1Department of Biomicrosystem Technology, Korea University, Seoul, 02481, Republic of Korea.
2Research Institute of Engineering and Technology, BK21 Plus Center for Creative Materials and Components, Korea University, Seoul, 02481, Republic of Korea.
3The Institute for High Technology Materials and Devices, Korea University, Seoul, 02481, Republic of Korea.
4Department of Bionano Engineering, Hanyang University, Ansan, 15588, Republic of Korea.
5Department of Materials Science and Engineering, Korea University, Seoul, 02841, Republic of Korea.
*Corresponding author
Abstract
Magnetic‐plasmonic nanoparticles have received considerable attention for widespread applications. These nanoparticles (NPs) exhibiting surface‐enhanced Raman scattering (SERS) activities are developed due to their potential in bio‐sensing applicable in non‐destructive and sensitive analysis with target‐specific separation. However, it is challenging to synthesize these NPs that simultaneously exhibit low remanence, maximized magnetic content, plasmonic coverage with abundant hotspots, and structural uniformity. Here, a method that involves the conjugation of a magnetic template with gold seeds via chemical binding and seed‐mediated growth is proposed, with the objective of obtaining plasmonic nanostructures with abundant hotspots on a magnetic template. To obtain a clean surface for directly functionalizing ligands and enhancing the Raman intensity, an additional growth step of gold (Au) and/or silver (Ag) atoms is proposed after modifying the Raman molecules on the as‐prepared magnetic‐plasmonic nanoparticles. Importantly, one‐sided silver growth occurred in an environment where gold facets are blocked by Raman molecules; otherwise, the gold growth is layer‐by‐layer. Moreover, simultaneous reduction by gold and silver ions allowed for the formation of a uniform bimetallic layer. The enhancement factor of the nanoparticles with a bimetallic layer is approximately 107. The SERS probes functionalized cyclic peptides are employed for targeted cancer‐cell imaging and separation.
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