한빛사 논문
Young-Hyeon An1, Joon Lee2,3, Dong Uk Son3, Dong Hyeon Kang2, Mihn Jeong Park2, Kyoung Won Cho2,4, Semin Kim5, Su-Hwan Kim2, Junghyeon Ko1, Myoung-Hoon Jang3, Jae Young Lee5, Dae-Hyeong Kim1,2,4, and Nathaniel S. Hwang1,2,*
1School of Chemical and Biological Engineering, Institute of Chemical Processes, Seoul National University, Seoul 08826, Republic of Korea
2Interdisciplinary Program in Bioengineering, Seoul National University, Seoul 08826, Republic of Korea
3Biosensor Laboratories Inc., Seoul National University, Seoul 08826, Republic of Korea
4Center for Nanoparticle Research, Institute for Basic Science (IBS), Seoul 08826, Republic of Korea
5School of Materials Science and Engineering, Gwangju Institute of Science and Technology, Gwangju 500-712, Republic of Korea
*Corresponding author
Abstract
We herein developed an iontophoretic transdermal drug delivery system for the effective delivery of electrically mobile drug nanocarriers (DNs). Our system consists of a portable and disposable reverse electrodialysis (RED) battery that generates electric power for iontophoresis through the ionic exchange. In addition, in order to provide a drug reservoir to the RED-driven iontophoretic system, an electroconductive hydrogel composed of polypyrrole-incorporated poly(vinyl alcohol) (PYP) was used. The PYP hydrogel facilitated electron transfer from the RED battery and accelerated the mobility of electrically mobile DNs released from the PYP hydrogel. In this study, we showed that fluconazole- or rosiglitazone-loaded DNs could be functionalized with charge-inducing agents, and DNs with charge modification resulted in facilitated transdermal transport via repulsive RED-driven iontophoresis. In addition, topical application and RED-driven iontophoresis of rosiglitazone-loaded DNs resulted in an effective antiobese condition displaying decreased bodyweight, reduced glucose level, and increased conversion of white adipose tissues to brown adipose tissues in vivo. Consequently, we highlight that this transdermal drug delivery platform would be extensively utilized for delivering diverse therapeutic agents in a noninvasive way.
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