한빛사 논문
Michael Taeyoung Hwang1,8, Mohammad Heiranian2,8, Yerim Kim2,8, Seungyong You1, Juyoung Leem2, Amir Taqieddin2, Vahid Faramarzi3, Yuhang Jing4,5, Insu Park1, Arend M. van der Zande1,2,6, Sungwoo Nam2,6,7, Narayana R. Aluru2,6,* & Rashid Bashir1,2,3,6,7,*
1Holonyak Micro and Nanotechnology Laboratory, University of Illinois, Urbana, IL, USA. 2Department of Mechanical Science and Engineering, University of Illinois, Urbana, IL, USA. 3Department of Bioengineering, University of Illinois, Urbana, IL, United States. 4Beckman Institute for Advanced Science and Technology, University of Illinois, Urbana, IL, USA. 5Department of Astronautical Science and Mechanics, Harbin Institute of Technology, 150001 Harbin, Heilongjiang, P. R. China. 6Materials Research Laboratory, University of Illinois, Urbana-Champaign, IL, USA. 7Department of Material Science and Engineering, University of Illinois, Urbana-Champaign, IL, USA. 8These authors contributed equally: Michael Taeyoung Hwang, Mohammad Heiranian, Yerim Kim.
*Correspondence to Narayana R. Aluru or Rashid Bashir.
Abstract
Field-effect transistor (FET)-based biosensors allow label-free detection of biomolecules by measuring their intrinsic charges. The detection limit of these sensors is determined by the Debye screening of the charges from counter ions in solutions. Here, we use FETs with a deformed monolayer graphene channel for the detection of nucleic acids. These devices with even millimeter scale channels show an ultra-high sensitivity detection in buffer and human serum sample down to 600 zM and 20 aM, respectively, which are ∼18 and ∼600 nucleic acid molecules. Computational simulations reveal that the nanoscale deformations can form ‘electrical hot spots’ in the sensing channel which reduce the charge screening at the concave regions. Moreover, the deformed graphene could exhibit a band-gap, allowing an exponential change in the source-drain current from small numbers of charges. Collectively, these phenomena allow for ultrasensitive electronic biomolecular detection in millimeter scale structures.
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