한빛사 논문
Jun Young Hong,1 Jaechul Lim,1 Fernando Carvalho,1 Jen Young Cho,1 Bharat Vaidyanathan,1,3 Shuang Yu,1 Charles Annicelli,1 W.K. Eddie Ip,1,4 and Ruslan Medzhitov1,2,5,*
1Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06510, USA
2Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA
3Present address: EMD Serono Research and Development Institute, Billerica, MA 01821, USA
4Present address: Department of Immunology, Mayo Clinic, Rochester, MN 55905, USA
5Lead Contact
*Correspondence
Abstract
Early life environmental exposure, particularly during perinatal period, can have a life-long impact on organismal development and physiology. The biological rationale for this phenomenon is to promote physiological adaptations to the anticipated environment based on early life experience. However, perinatal exposure to adverse environments can also be associated with adult-onset disorders. Multiple environmental stressors induce glucocorticoids, which prompted us to investigate their role in developmental programming. Here, we report that perinatal glucocorticoid exposure had long-term consequences and resulted in diminished CD8 T cell response in adulthood and impaired control of tumor growth and bacterial infection. We found that perinatal glucocorticoid exposure resulted in persistent alteration of the hypothalamic-pituitary-adrenal (HPA) axis. Consequently, the level of the hormone in adults was significantly reduced, resulting in decreased CD8 T cell function. Our study thus demonstrates that perinatal stress can have long-term consequences on CD8 T cell immunity by altering HPA axis activity.
논문정보
관련 링크
연구자 키워드
소속기관 논문보기
관련분야 논문보기
해당논문 저자보기