한빛사 논문
Jongdoo Kim1, Jaehong Kim2,3,* and Jong-Sup Bae4,*
1Cancer Control Team, Gachon University Gil Medical Center, Incheon, Republic of Korea; 2Department of Biochemistry, School of Medicine, Gachon University, Incheon, Republic of Korea; 3Department of Health Sciences and Technology, Gachon Advanced Institute for Health Science and Technology, Gachon University, Incheon, Republic of Korea and 4College of Pharmacy, CMRI, Research Institute of Pharmaceutical Sciences, Daegu, Republic of Korea
*Correspondence: Dr Jaehong Kim, Department of Biochemistry, School of Medicine, Gachon University, 155 Gaetbeol-ro Yeonsu-Gu, Incheon 21999, Republic of Korea.
or Dr J-S Bae, College of Pharmacy, Kyungpook National University, 80 Daehak-ro, Buk-gu, Daegu 41566, Republic of Korea.
Abstract
Evidence indicates that hypoxia and oxidative stress can control metabolic reprogramming of cancer cells and other cells in tumor microenvironments and that the reprogrammed metabolic pathways in cancer tissue can also alter the redox balance. Thus, important steps toward developing novel cancer therapy approaches would be to identify and modulate critical biochemical nodes that are deregulated in cancer metabolism and determine if the therapeutic efficiency can be influenced by changes in redox homeostasis in cancer tissues. In this review, we will explore the molecular mechanisms responsible for the metabolic reprogramming of tumor microenvironments, the functional modulation of which may disrupt the effects of or may be disrupted by redox homeostasis modulating cancer therapy.
논문정보
관련 링크
연구자 키워드
관련분야 연구자보기
소속기관 논문보기
관련분야 논문보기
해당논문 저자보기