한빛사 논문
Bobae An1,2,†, Jihye Kim1,†, Kyungjoon Park1,†, Sukwon Lee1,3,†, Sukwoon Song1,†, Sukwoo Choi1,*
1School of Biological Sciences, College of Natural Sciences, Seoul National University, Seoul, Korea; 2Department of Neurobiology, Duke University, Durham, United States; 3Department of Neural Development and Disease, Korea Brain Research Institute, Daegu, Korea
*For correspondence: Sukwoo Choi
†These authors contributed equally to this work
Abstract
There has been a longstanding debate on whether original fear memory is inhibited or erased after extinction. One possibility that reconciles this uncertainty is that the inhibition and erasure mechanisms are engaged in different phases (early or late) of extinction. In this study, using single-session extinction training and its repetition (multiple-session extinction training), we investigated the inhibition and erasure mechanisms in the prefrontal cortex and amygdala of rats, where neural circuits underlying extinction reside. The inhibition mechanism was prevalent with single-session extinction training but faded when single-session extinction training was repeated. In contrast, the erasure mechanism became prevalent when single-session extinction training was repeated. Moreover, ablating the intercalated neurons of amygdala, which are responsible for maintaining extinction-induced inhibition, was no longer effective in multiple-session extinction training. We propose that the inhibition mechanism operates primarily in the early phase of extinction training, and the erasure mechanism takes over after that.
논문정보
관련 링크
연구자 키워드
연구자 ID
관련분야 연구자보기
소속기관 논문보기
관련분야 논문보기