한빛사 논문
Myungjin Kim1,6, Alyson Sujkowski2,6, Sim Namkoong1,4, Bondong Gu1, Tyler Cobb2, Boyoung Kim1, Allison H. Kowalsky1, Chun-Seok Cho1, Ian Semple1, Seung-Hyun Ro1,5, Carol Davis1, Susan V. Brooks1, Michael Karin3, Robert J. Wessells2,* & Jun Hee Lee1,*
1 Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI 48109, USA.
2 Department of Physiology, Wayne State University School of Medicine, Detroit, MI 48201, USA.
3 Department of Pharmacology, University of California San Diego, La Jolla, CA 92093, USA.
4 Present address: Department of Biochemistry, College of Natural Sciences, Kangwon National University, Chuncheon, Gangwon 24341, Republic of Korea.
5 Present address:Department of Biochemistry, University of Nebraska, Lincoln, NE 68588, USA.
6 These authors contributed equally: Myungjin Kim, Alyson Sujkowski.
*Correspondence to Robert J. Wessells or Jun Hee Lee
Abstract
Exercise is among the most effective interventions for age-associated mobility decline and metabolic dysregulation. Although long-term endurance exercise promotes insulin sensitivity and expands respiratory capacity, genetic components and pathways mediating the metabolic benefits of exercise have remained elusive. Here, we show that Sestrins, a family of evolutionarily conserved exercise-inducible proteins, are critical mediators of exercise benefits. In both fly and mouse models, genetic ablation of Sestrins prevents organisms from acquiring metabolic benefits of exercise and improving their endurance through training. Conversely, Sestrin upregulation mimics both molecular and physiological effects of exercise, suggesting that it could be a major effector of exercise metabolism. Among the various targets modulated by Sestrin in response to exercise, AKT and PGC1α are critical for the Sestrin effects in extending endurance. These results indicate that Sestrin is a key integrating factor that drives the benefits of chronic exercise to metabolism and physical endurance.
논문정보
관련 링크
연구자 키워드
소속기관 논문보기
관련분야 논문보기
해당논문 저자보기