한빛사 논문
Homan Kanga, Wesley R. Stilesa, Yoonji Baeka, Shinsuke Nomuraa, Kai Baoa, Shuang Hua,†, G. Kate Parka, Min Joo Joa, Hoseok Ib, Jean‐Luc Collc, Brian P. Rubind, Hak Soo Choia,*
aGordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
bDepartment of Thoracic and Cardiovascular Surgery, Pusan National University School of Medicine and Biomedical Research Institute, Pusan National University Hospital, Busan 49241, Republic of Korea
cCancer Targets & Experimental Therapeutics, Institute for Advanced Biosciences, University of Grenoble Alpes, INSERM-U1209, CNRS-UMR 5309, Grenoble 38000, France
dDepartments of Pathology and Cancer Biology, Robert J. Tomsich Pathology and Laboratory Medicine Institute and Lerner Research Institute and Taussig Cancer Center, Cleveland Clinic, Cleveland, OH 44195, USA
†Present address: Department of Nuclear Medicine, West China Hospital Sichuan University, Chengdu 610041, China
*To whom correspondence should be addressed.
Abstract
Advances in molecular imaging modalities have accelerated the diagnosis and treatment of human diseases. However, tumors less than 1 cm in size still remain difficult to localize by conventional means because of the difficulty in specific targeting/delivery to the tumor site. Furthermore, high nonspecific uptake in the major organs and persistent background retention results in low tumor‐to‐background ratio. The targeting and therapy of gastrointestinal stromal tumors (GIST) using nonsticky and renal clearable theranostic nanoparticles (a.k.a. H‐Dots) are demonstrated. H‐Dots not only target GIST for image‐guided surgery, but also tailor the fate of anticancer drugs such as imatinib (IM) to the tumor site resulting in efficient treatment of unresectable GIST. In addition, H‐Dots can monitor targetability, pharmacokinetics, and drug delivery, while also showing therapeutic efficacy in GIST‐bearing xenograft mice following surgical resection. More importantly, IM loaded H‐Dots exhibit lower uptake into the immune system, improved tumor selectivity, and increased tumor suppression compared to free IM, which accumulates in the spleen/liver. Precisely designed H‐Dots can be used as a promising theranostic nanoplatform that can potentially reduce the side effects of conventional chemotherapies.
Keywords : drug delivery, nanoparticles, optical imaging, renal clearance, theranostics
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