한빛사 논문
Boram Seo1,5, Kyungchan Jeon1, Sunghyun Moon1,4, Kiuk Lee4, Woon-Ki Kim1, Hyein Jeong1, Kwang Hyun Cha6, Mi Young Lim7, Wondae Kang8, Mi-Na Kweon9, Joohon Sung10, Won Kim11, Joo-Hong Park5, GwangPyo Ko1,2,3,4,12,*
1 Department of Environmental Health Sciences, Graduate School of Public Health, Seoul National University, Seoul, Korea
2 Bio-MAX/N-Bio, Seoul National University, Seoul, Korea
3 Center for Human and Environmental Microbiome, Institute of Health and Environment, Seoul National University, Seoul, Korea
4 KoBioLabs, Inc., Seoul, Korea
5 School of Biological Sciences, Seoul National University, Seoul, Korea
6 Functional Food Center, Korea Institute of Science and Technology (KIST), Gangneung, Korea
7 Research Group of Healthcare, Korea Food Research Institute, Wanju, Korea
8 Department of Life Sciences, Pohang University of Science and Technology, Pohang, Korea
9 Mucosal Immunology Laboratory, Department of Convergence Medicine, University of Ulsan College of Medicine/Asan Medical Center, Seoul, Korea
10 Department of Epidemiology, Graduate School of Public Health, Seoul National University, Seoul, Korea
11 Division of Gastroenterology and Hepatology, Department of Internal Medicine, Seoul Metropolitan Government Seoul National University Boramae Medical Center, Seoul, Korea
12 Lead Contact
*Corresponding author : GwangPyo Ko
Abstract
Although a link between the gut microbiota and alcohol-related liver diseases (ALDs) has previously been suggested, the causative effects of specific taxa and their functions have not been fully investigated to date. Here, we analyze the gut microbiota of 410 fecal samples from 212 Korean twins by using the Alcohol Use Disorders Identification Test (AUDIT) scales to adjust for host genetics. This analysis revealed a strong association between low AUDIT scores and the abundance of the butyrate-producing genus Roseburia. When Roseburia spp. are administered to ALD murine models, both hepatic steatosis and inflammation significantly improve regardless of bacterial viability. Specifically, the flagellin of R. intestinalis, possibly through Toll-like receptor 5 (TLR5) recognition, recovers gut barrier integrity through upregulation of the tight junction protein Occludin and helps to restore the gut microbiota through elevated expression of IL-22 and REG3γ. Our study demonstrates that Roseburia spp. improve the gut ecosystem and prevent leaky gut, leading to ameliorated ALDs.
Keywords : microbiome; alcohol liver diseases; roseburia; fat liver diseases; hepatitis; occludin; liver steatosis; leaky gut
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