한빛사 논문
Ina Yoon1, Miso Nam2, Hoi Kyoung Kim1, Hee-Sun Moon1, Sungmin Kim1, Jayun Jang3, Ji Ae Song3, Seung Jae Jeong1, Sang Bum Kim1, Seongmin Cho3, YounHa Kim3, Jihye Lee1, Won Suk Yang1, Hee Chan Yoo4, Kibum Kim4,5, Min-Sun Kim2,*, Aerin Yang6, Kyukwang Cho6, Hee-Sung Park6, Geum-Sook Hwang2, Kwang Yeon Hwang7, Jung Min Han4,5, Jong Hyun Kim1,†,‡,§, Sunghoon Kim1,3,‡,§
1 Medicinal Bioconvergence Research Center and College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea.
2 Integrated Metabolomics Research Group, Western Seoul Center, Korea Basic Science Institute, Seoul 03759, Republic of Korea.
3 Department of Molecular Medicine and Biopharmaceutical Sciences and Graduate School for Convergence Technologies, Seoul National University, Seoul 08826, Republic of Korea.
4 Yonsei Institute of Pharmaceutical Sciences, College of Pharmacy, Yonsei University, Incheon 21983, Republic of Korea.
5 Department of Integrated OMICS for Biomedical Science, Yonsei University, Seoul 03722, Republic of Korea.
6 Department of Chemistry, Korea Advanced Institute of Science and Technology, Daejeon 34141, Republic of Korea.
7 Division of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul 02841, Republic of Korea.
‡ These authors contributed equally to this work.
* Present address: Food Analysis Center, Korea Food Research Institute, Wanju 55365, Republic of Korea.
† Present address: Nextgen Bioscience, Seongnam 13494, Republic of Korea.
§ Corresponding author : Jong Hyun Kim, Sunghoon Kim
Abstract
Despite the importance of glucose and amino acids for energy metabolism, interactions between the two nutrients are not well understood. We provide evidence for a role of leucyl-tRNA synthetase 1 (LARS1) in glucose-dependent control of leucine usage. Upon glucose starvation, LARS1 was phosphorylated by Unc-51 like autophagy activating kinase 1 (ULK1) at the residues crucial for leucine-binding. The phosphorylated LARS1 showed decreased leucine-binding, which may inhibit protein synthesis and help save energy. Leucine, not used to anabolic process, may be available to catabolic pathway for energy generation. The LARS1-mediated changes in leucine utilization might help support cell survival deprived of glucose. Thus, dependent on the availability of glucose, LARS1 may help regulate whether leucine is used for protein synthesis or energy production.
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