한빛사 논문
POSTECH
Joohee Kim,†,‡ Jaeyoon Kim,§ Minjae Ku,†,‡ Eunkyung Cha,†,‡ Seoyoung Ju,†,‡ Won Yeong Park,∥ Ki Hean Kim,∥ Dai Woo Kim,⊥ Per-Olof Berggren,*,§,# and Jang-Ung Park*,†,‡
† Nano Science Technology Institute, Department of Materials Science and Engineering, Yonsei University, Seoul 03722, Republic of Korea
‡ Center for Nanomedicine, Institute for Basic Science (IBS), Yonsei University, Seoul 03722, Republic of Korea
§ Division of Integrative Biosciences & Biotechnology, Pohang University of Science and Technology, Pohang, Gyeongbuk 37673,Republic of Korea
∥ Department of Mechanical Engineering, Pohang University of Science and Technology, Pohang, Gyeongbuk 37673, Republic of Korea
⊥ Department of Ophthalmology, School of Medicine, Kyungpook National University, Daegu 41944, Republic of Korea
# The Rolf Luft Research Center for Diabetes and Endocrinology, Karolinska Institutet, Karolinska University Hospital L1, SE-17176 Stockholm, Sweden
*Corresponding Authors : Per-Olof Berggren, Jang-Ung Park
Joohee Kim and Jaeyoon Kim contributed equally to this work.
Abstract
Intraocular islet transplantation was investigated as a new procedure to treat diabetes. The development of this procedure requires close monitoring of the function of both eye and islet graft. We developed a soft, smart contact lens to monitor the intraocular pressure and applied this for noninvasive monitoring in association with the intraocular islet transplantation in diabetes. A strain sensor inside the lens can detect detailed changes in intraocular pressure by focusing the strain only in the desired, selective area of the contact lens. In addition, this smart contact lens can transmit the real-time value of the intraocular pressure wirelessly using an antenna. The wireless measurement of intraocular pressure that was obtained using this contact lens had a high correlation with the intraocular pressure measured by a rebound tonometer, thereby proving the good accuracy of the contact lens sensor. In the initial period, a slight elevation of intraocular pressure was observed, but the pressure returned to normal in the initial period after the transplantation. This type of monitoring will provide important information on potential changes in the intraocular pressure associated with the transplantation procedure, and it enables appropriate clinical safety steps to be taken, if needed.
KEYWORDS : Islet transplantation, diabetes, intraocular pressure, eye monitoring system, smart contact lens
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