한빛사 논문
Chul-Ho Kima,c, Jae Hoon Bahna, Seong-Ho Leea, Gye-Yeop Kima, Seung-Ik Junb, Keunho Leeb, Seung Joon Baeka,*
aDepartment of Pathobiology, College of Veterinary Medicine, University of Tennessee, Knoxville, TN 37996, USA
bPSM America Inc., Colorado Springs, CO 80916, USA
cDepartment of Otolaryngology and Center for Cell Death Regulating Biodrugs, School of Medicine, Ajou University, Suwon, South Korea
*Corresponding author
Abstract
Plasma is generated by ionizing neutral gas molecules, resulting in a mixture of energy particles, including electrons and ions. Recent progress in the understanding of non-thermal atmospheric plasma has led to applications in biomedicine. However, the exact molecular mechanisms involved in plasma-induced cell growth arrest are unclear. In this study, we investigated the feasibility of non-thermal atmospheric plasma treatment for cancer therapy and examined the mechanism by which plasma induces anti-proliferative properties and cell death in human colorectal cancer cells. Non-thermal atmospheric plasma induced cell growth arrest and induced apoptosis. In addition, plasma reduced cell migration and invasion activities. As a result, we found that plasma treatment to the cells increases β-catenin phosphorylation, suggesting that β-catenin degradation plays a role at least in part in plasma-induced anti-proliferative activity. Therefore, non-thermal atmospheric plasma constitutes a new biologic tool with the potential for therapeutic applications that modulate cell signaling and function.
Keywords : Non-thermal atmospheric plasma; Apoptosis; Colorectal cancer; Growth arrest; β-Catenin
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