한빛사 논문
Jongha Lee1,2,10, Hye Rim Cho1,3,10, Gi Doo Cha1,2,10, Hyunseon Seo1,2,4, Seunghyun Lee3, Chul-Kee Park5, Jin Wook Kim5, Shutao Qiao6, Liu Wang6, Dayoung Kang1,2, Taegyu Kang1,2, Tomotsugu Ichikawa7, Jonghoon Kim1,2, Hakyong Lee1,2, Woongchan Lee1,2, Sanghoek Kim8, Soon-Tae Lee9, Nanshu Lu6, Taeghwan Hyeon1,2, Seung Hong Choi1,3,* & Dae-Hyeong Kim1,2,*
1 Center for Nanoparticle Research, Institute for Basic Science (IBS), Seoul 08826, Republic of Korea.
2 School of Chemical and Biological Engineering, Institute of Chemical Processes, Seoul National University, Seoul 08826, Republic of Korea.
3 Department of Radiology, Seoul National University College of Medicine, Seoul 03080, Republic of Korea.
4 Center for Biomaterials, Korea Institute of Science and Technology, Seoul 02792, Republic of Korea.
5 Department of Neurosurgery, Seoul National University College of Medicine, Seoul 03080, Republic of Korea.
6 Center for Mechanics of Solids, Structures and Materials, Department of Aerospace Engineering and Engineering Mechanics, University of Texas at Austin, Austin, TX 78712, USA.
7 Department of Neurological surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama 700-8558, Japan.
8 Department of Electronics and Radio Engineering, Kyung Hee University, Gyeonggi 17194, Republic of Korea.
9 Department of Neurology, Seoul National University College of Medicine, Seoul 03080, Republic of Korea.
10 These authors contributed equally: Jongha Lee, Hye Rim Cho, Gi Doo Cha.
*Correspondence to Seung Hong Choi or Dae-Hyeong Kim
Abstract
Implantation of biodegradable wafers near the brain surgery site to deliver anti-cancer agents which target residual tumor cells by bypassing the blood-brain barrier has been a promising method for brain tumor treatment. However, further improvement in the prognosis is still necessary. We herein present novel materials and device technologies for drug delivery to brain tumors, i.e., a flexible, sticky, and biodegradable drug-loaded patch integrated with wireless electronics for controlled intracranial drug delivery through mild-thermic actuation. The flexible and bifacially-designed sticky/hydrophobic device allows conformal adhesion on the brain surgery site and provides spatially-controlled and temporarily-extended drug delivery to brain tumors while minimizing unintended drug leakage to the cerebrospinal fluid. Biodegradation of the entire device minimizes potential neurological side-effects. Application of the device to the mouse model confirms tumor volume suppression and improved survival rate. Demonstration in a large animal model (canine model) exhibited its potential for human application.
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