한빛사 논문
한양대학교 의과대학
Yoon Jung Yanga, Yun-Chul Hongb,c, Se-Young Ohd,e,*, Min-Seon Parkf, Ho Kimg, Jong-Han Leemh, Eun-Hee Hai
a Department of Preventive Medicine, College of Medicine, Hanyang University, Seoul, Republic of Korea
b Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea
c Institute of Environmental Medicine, Seoul National University Medical Research Center, Seoul, Republic of Korea
d Department of Food and Nutrition, Kyung Hee University, Seoul, Republic of Korea
e Research Institute of Human Ecology, Kyung Hee University, Seoul, Republic of Korea
f Department of Family Medicine, Seoul National University Hospital, Seoul, Republic of Korea
g Department of Epidemiology and Biostatistics, Seoul National University School of Public Health, Seoul, Republic of Korea
h Department of Occupational and Environmental Medicine, Inha University Hospital, Incheon, Republic of Korea
i Department of Preventive Medicine, Ewha Womans University, Seoul, Republic of Korea
*Corresponding author : Se-Young Oh
Abstract
Bisphenol A (BPA) is widely used in the production of polycarbonate plastics and epoxy resins. There is increasing health concerns regarding low-level exposure to BPA among the general population. The aim of this study was to determine the association between BPA exposure with oxidative stress and inflammation in adult populations. A cross-sectional study was conducted. This study included 485 adults (259 men, 92 premenopausal women, and 134 postmenopausal women) living in general communities within large cities. Urinary concentrations of BPA, malondialdehyde (MDA), and 8-hydroxydeoxyguanosine (8-OHdG), white blood cell (WBC) count, and C-reactive protein (CRP) were measured. Multivariate analyses were applied to determine the associations of BPA exposure with oxidative stress and inflammation. The geometric means of urinary BPA for men, premenopausal women, and postmenopausal women were 0.53, 0.61, and 0.58 μg/g cr, respectively. The urinary BPA concentrations were positively associated with MDA, 8-OHdG, and CRP levels in the postmenopausal women; however, such associations did not exist in men and premenopausal women. The findings of this study suggest that BPA exposure would promote oxidative stress and inflammation, in which postmenopausal women are likely to be more susceptible to BPA-induced health effects.
Keywords : Bisphenol A; Oxidative stress; Inflammation; Postmenopausal woman; Cross-sectional studies
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