한빛사 논문
Kyoung Won Cho1,2,4, Seok Joo Kim1,2,4, Jaemin Kim1,2,4, Seuk Young Song2,4, Wang Hee Lee1,2, Liu Wang3, Min Soh1,2, Nanshu Lu3, Taeghwan Hyeon1,2, Byung-Soo Kim2,* & Dae-Hyeong Kim1,2,*
1 Center for Nanoparticle Research, Institute for Basic Science (IBS), Seoul 08826, Republic of Korea.
2 School of Chemical and Biological Engineering, Seoul National University, Seoul 08826, Republic of Korea.
3 Center for Mechanics of Solids, Structures, and Materials, Department of Aerospace Engineering and Engineering Mechanics, Texas Materials Institute, University of Texas at Austin, Austin, TX, USA.
4 These authors contributed equally: Kyoung Won Cho, Seok Joo Kim, Jaemin Kim, Seuk Young Song.
*Correspondence to Byung-Soo Kim or Dae-Hyeong Kim
Abstract
Industrial applications of anchorage-dependent cells require large-scale cell culture with multifunctional monitoring of culture conditions and control of cell behaviour. Here, we introduce a large-scale, integrated, and smart cell-culture platform (LISCCP) that facilitates digital mass culture of anchorage-dependent cells. LISCCP is devised through large-scale integration of ultrathin sensors and stimulator arrays in multiple layers. LISCCP provides real-time, 3D, and multimodal monitoring and localized control of the cultured cells, which thereby allows minimizing operation labour and maximizing cell culture performance. Wireless integration of multiple LISCCPs across multiple incubators further amplifies the culture scale and enables digital monitoring and local control of numerous culture layers, making the large-scale culture more efficient. Thus, LISCCP can transform conventional labour-intensive and high-cost cell cultures into efficient digital mass cell cultures. This platform could be useful for industrial applications of cell cultures such as in vitro toxicity testing of drugs and cosmetics and clinical scale production of cells for cell therapy.
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