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조회 83  인쇄하기 주소복사 트위터 공유 페이스북 공유 
Organic acid conjugated phenolic compounds of hardy kiwifruit (Actinidia arguta) and their NF-κB inhibitory activity

Jong Hoon Ahna, Youngki Parkb, Yang Hee Joa, Seon Beom Kima, Sang Won Yeona, Jun Gu Kima, Ayman Turka, Jin Yong Songa, Youngsoo Kima, Bang Yeon Hwanga, Mi Kyeong Leea,*

a College of Pharmacy, Chungbuk National University, Cheongju 28160, Republic of Korea
b Division of Special Purpose Trees, National Institute of Forest Science, Suwon 16631, Republic of Korea

*Corresponding author : Mi Kyeong Lee

Abstract
Nine new compounds, argutinosides A-I (1–9) together with 20 known compounds (10–29), were isolated from the fruits of Actinidia arguta. Using spectral analysis, the structures of the isolated compounds were identified as 10 succinic acid derivatives, 11 quinic acid derivatives, two shikimic acid derivatives and six citric acid derivatives. The NF-κB transcriptional inhibitory activity of the compounds was evaluated using RAW 264.7 macrophages cells induced by lipopolysaccharide. Among four groups of different organic acid derivatives, the quinic acid derivatives inhibited NF-κB transcriptional activity with an IC50 value of 4.0 μM. Fruit is rich in organic acid and secondary metabolites, which differ depending on the type of fruit. Our present study showed the presence of various organic acids conjugates including nine new 2-methylsuccinic acid phenolic conjugates in kiwiberry and compared their biological activities. This will contribute to application of kiwiberry and also the diversity of different fruits.

Chemical compounds studied in this article
3-O-trans-p-Coumaroyl shikimic acid (PubChem CID: 5280555); 1,5,6-Trimethyl citrate (PubChem CID: 74112)

Keywords : Actinidia arguta; 2-methylsuccinic acid derivatives; Quinic acid derivatives; NF-κB transcriptional inhibitory activity; Shikimic acid derivatives; Citric acid derivatives

논문정보
- 형식: Research article
- 게재일: 2019년 10월 (BRIC 등록일 2019-10-24)
- 연구진: 국내연구진 태극기
- 분야: Food_Technology
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