한빛사 논문
경상대학교 수의과대학
Abstract
Alisha Wehdnesday Bernardo Reyes, Lauren Togonon Arayan, Tran Xuan Ngoc Huy, Son Hai Vu, Chang Keun Kang, Wongi Min, Hu Jang Lee, John Hwa Lee, Suk Kim*
Institute of Animal Medicine, College of Veterinary Medicine, Gyeongsang National University, Jinju, 52828, Republic of Korea
*Corresponding author : Suk Kim
Abstract
We investigated the involvement of chemokine receptor type 4 (CXCR4) signaling on the outcome of Brucella (B.) abortus 544 infection in murine macrophages and in a mouse model. CXCR4 manipulation were first evaluated for Brucella invasion and intracellular survival efficiency, mitogen-activated protein kinases (ERK1/2, JNK, p38α) activation and generation of nitric oxide (NO), and then in the splenic bacterial proliferation and cytokine production in BALB/c mice. CXCR4 blockade is involved in the successful control of Brucella invasion, reduction of ERK1/2 phosphorylation and inhibition of nitric oxide release from macrophages. Furthermore, using a reported CXCR4-specific antagonist AMD3100 resulted in splenomegaly but attenuated Brucella proliferation in these organs with elevated serum levels of MCP-1, TNF and IL-12. These findings provide insights on the contribution of CXCR4 signaling in the phagocytic pathway and immune modulation during B. abortus infection.
Keywords : AMD3100; B. abortus; Cytokines; CXCR4; Invasion; MAPKs
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