한빛사 논문
Abstract
Joo-Hyung Choia, Mi-Kyeong Koa, Sung Ho Shina, Su-Hwa Youa, Hye-Eun Joa, Hyundong Joa, Min Ja Leea, Su-Mi Kima, Jong-Soo Leeb, Byounghan Kima, Jong-Hyeon Parka,*
a Animal and Plant Quarantine Agency, 177 Hyeoksin-8 ro, Gimcheon City, Gyeongsangbuk-do, 39660, Republic of Korea
b Veterinary College, Chungnam National University, Yuseonggu, Daejeon, 34134, Republic of Korea
*Corresponding author : Jong-Hyeon Park
Abstract
Foot-and-mouth disease (FMD) is a highly contagious disease and causes economic damage at a national level. In particular, the type O FMD virus (FMDV) is a serotype that causes FMD outbreaks most frequently in the world. In recent years, Southeast Asia (SEA), Middle East-South Asia (ME-SA), and Cathay topotype-mediated FMD are prevalent in Asia, among which the SEA and ME-SA topotypes cause a majority of the outbreaks. The SEA topotype virus is more likely to infect both cattle and pigs simultaneously, thereby resulting in more severe damages; thus, it is necessary to study the protection ability of the candidate vaccines of this topotype after immunization. In this study, an experimental vaccine for pigs was produced using a vaccine strain that contains the structural protein of the O Taiwan97 strain, which was derived from the Cathay topotype, and its effect was evaluated. In the immunization test in pigs and cattle, the antibody titers were found to be elevated two weeks after immunization and very high titers of neutralizing antibodies were formed after four weeks. After the second inoculation, very high titers of neutralizing antibodies were produced in both species in the fourth week after immunization, and the antibodies maintained for up to six months and three months in cattle and pigs, respectively. No significant immunological difference in antibody production was observed in cattle and pigs. This study confirmed that complete protection from the challenge of the SEA topotype virus (O/Jincheon/SKR/2014), although the antibody titers against O/Jincheon/SKR/2014 strain were not that high, was achieved through immunization with the newly developed Cathay topotype vaccine in pigs.
Keywords : FMD; Type O; Vaccine; Protection; Pig
논문정보
관련 링크
연구자 키워드
관련분야 연구자보기
소속기관 논문보기
관련분야 논문보기
해당논문 저자보기