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이현 (Hyun Lee)  |
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한양대학교 의과대학 |
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Increased Mortality in Patients with Corticosteroid-dependent Asthma: A Nationwide Population-based Study
 Authors and Affiliations
 Authors and Affiliations
Hyun Lee1, Jiin Ryu2, Eunwoo Nam2, Sung Jun Chung1, Yoomi Yeo1, Dong Won Park1, Tai Sun Park1, Ji-Yong Moon1, Tae-Hyung Kim1, Jang Won Sohn1, Ho Joo Yoon1 and Sang-Heon Kim1,*
1 Department of Internal Medicine, Hanyang University College of Medicine, Seoul, Korea
2 Biostatistical Consulting and Research Lab, Medical Research Collaborating Center, Hanyang University, Seoul, Korea
*Address Correspondence and Reprint Requests to Dr Sang-Heon Kim, MD, Ph.D., Department of Internal Medicine, Hanyang University College of Medicine, 222 Wangsimni-ro, Seongdong-gu, Seoul 04763, Korea.
Abstract Background : Chronic systemic corticosteroid (CS) therapy is associated with an increased risk of mortality in patients with many chronic diseases. However, it has not been elucidated whether chronic, systemic CS therapy is associated with increased mortality in patients with asthma. The aim of this study was to determine the effects of chronic, systemic CS therapy on long-term mortality in adult patients with asthma.
Methods : A population-based matched cohort study of men and women aged 18 years or older with asthma was performed using the Korean National Health Insurance Service database from 2005 to 2015. Hazard ratio (HR) with 95% confidence interval (CI) for all-cause mortality among patients in the CS-dependent cohort (CS use >6 months during baseline period) relative to those in the CS-independent cohort (CS use <6 months during baseline period) was evaluated.
Results : The baseline cohort included 466 941 patients with asthma, of whom 8334 were CS-dependent and 456 607 were CS-independent. After 1:1 matching, 8334 subjects with CS-independent asthma were identified. The HR of mortality associated with CS-dependent asthma relative to CS-independent asthma was 2.17 (95% CI, 2.04–2.31). In patients receiving low-dose CS, the HR was 1.84 (95% CI, 1.69–2.00), and that for those receiving high-dose CS was 2.56 (95% CI, 2.35–2.80).
Conclusions : In this real-world, clinical practice, observational study, chronic use of systemic CS was associated with increased risk of mortality in patients with asthma, with a significant dose-response relationship between systemic CS use and long-term mortality.
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논문정보 |
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- 형식: Research article - 게재일: 2019년 09월 (BRIC 등록일 2019-09-16) - 연구진: 국내연구진 - 분야: Medicine
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관련 인터뷰 |
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1. 논문관련 분야의 소개, 동향, 전망을 설명, 연구과정에서 생긴 에피소드
1) 논문 관련 분야의 소개
대부분의 천식 환자는 흡입 스테로이드 치료로 천식이 잘 조절되지만, 통상적인 치료로 조절되지 않은 일부 천식 환자는 장기간 전신 스테로이드를 사용해야만 합니다. 이러한 상태를 스테로이드 의존 천식이라고 합니다. 전신 스테로이드의 사용은 천식을 조절할 수 있도록 도움을 주기도 하지만, 장기간 사용하게 되면 폐렴, 결핵, 당뇨, 부신 기능 부전, 골다공증... |
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hippoc (2019-11-03 13:27) |
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의약품 GMP 품질관리 실무
사전접수: ~2019.12.13
날짜: 2019.12.12~13
장소: 충북 청주시 흥덕구 오송읍 오송생명 1로 194-41 기업연구관 1관 충북산학융합본부 1층 강의실 |
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