한빛사 논문
John Eoma,1, Jeong Jin Kima,1, Seul Gi Yoonb, Haengdueng Jeonga, Soojin Sonb, Jae Bong Leea, Jihye Yooa, Hyun Ju Seob, Yejin Choa, Ku Sul Kima, Kyung Mi Choia, Il Yong Kimb, Hui-Young Leec,d, Ki Taek Nama, Peter Cresswelle,2, Je Kyung Seongb,f,g,2, and Jun-Young Seoa,2
aSeverance Biomedical Science Institute, Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of Medicine, 03722 Seoul, Republic of Korea; bKorea Mouse Phenotyping Center, Seoul National University, 08826 Seoul, Republic of Korea; cDepartment of Molecular Medicine, School of Medicine, Gachon University, 21999 Incheon, Republic of Korea; dLee Gil Ya Cancer and Diabetes Institute, Gachon University, 21999 Incheon, Republic of Korea; eDepartment of Immunobiology, Yale University School of Medicine, New Haven, CT 06520; fLaboratory of Developmental Biology and Genomics, BK21 Program Plus for Advanced Veterinary Science, Research Institute for Veterinary Science, College of Veterinary Medicine, Seoul National University, 08826 Seoul, Republic of Korea; and gInterdisciplinary Program for Bioinformatics, Program for Cancer Biology, BIO-MAX/N-Bio Institute, Seoul National University, 08826 Seoul, Republic of Korea
1J.E. and J.J.K. contributed equally to this work.
2To whom correspondence may be addressed.
Abstract
Viperin is an interferon (IFN)-inducible multifunctional protein. Recent evidence from high-throughput analyses indicates that most IFN-inducible proteins, including viperin, are intrinsically expressed in specific tissues; however, the respective intrinsic functions are unknown. Here we show that the intrinsic expression of viperin regulates adipose tissue thermogenesis, which is known to counter metabolic disease and contribute to the febrile response to pathogen invasion. Viperin knockout mice exhibit increased heat production, resulting in a reduction of fat mass, improvement of high-fat diet (HFD)-induced glucose tolerance, and enhancement of cold tolerance. These thermogenic phenotypes are attributed to an adipocyte-autonomous mechanism that regulates fatty acid β-oxidation. Under an HFD, viperin expression is increased, and its function is enhanced. Our findings reveal the intrinsic function of viperin as a novel mechanism regulating thermogenesis in adipose tissues, suggesting that viperin represents a molecular target for thermoregulation in clinical contexts.
metabolism, fatty acid β-oxidation, innate immunity, viperin, thermogenesis
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