한빛사 논문
Ji Hoon Ahn1,6, Hyunsoo cho2,6, Jun-Hee Kim3,6, Shin Heun Kim4, Je-Seok Ham3, intae Park2, Sang Heon Suh1, Seon Pyo Hong2, Joo-Hye Song2, Young-Kwon Hong5, Yong Jeong1,3,4, Sung-Hong Park3,4,7* & Gou Young Koh1,2,7*
1Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, South Korea. 2Center for Vascular Research, Institute for Basic Science, Daejeon, South Korea. 3Department of Bio and Brain Engineering, KAIST, Daejeon, South Korea. 4Program of Brain and Cognitive Engineering, KAIST, Daejeon, South Korea. 5Department of Surgery, Department of Biochemistry and Molecular Biology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA. 6These authors contributed equally: Ji Hoon Ahn, Hyunsoo Cho, Jun-Hee Kim. 7These authors jointly supervised this work: Sung-Hong Park & Gou Young Koh.
*Correspondence to Sung-Hong Park or Gou Young Koh.
Abstract
Recent work has shown that meningeal lymphatic vessels (mLVs), mainly in the dorsal part of the skull, are involved in the clearance of cerebrospinal fluid (CSF), but the precise route of CSF drainage is still unknown. Here we reveal the importance of mLVs in the basal part of the skull for this process by visualizing their distinct anatomical location and characterizing their specialized morphological features, which facilitate the uptake and drainage of CSF. Unlike dorsal mLVs, basal mLVs have lymphatic valves and capillaries located adjacent to the subarachnoid space in mice. We also show that basal mLVs are hotspots for the clearance of CSF macromolecules and that both mLV integrity and CSF drainage are impaired with ageing. Our findings should increase the understanding of how mLVs contribute to the neuropathophysiological processes that are associated with ageing.
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TOP52019년 선정
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