한빛사 논문
Soon-Jung Park1,9, Ri Youn Kim2,9, Bong-Woo Park3,4,9, Sunghun Lee2,9, Seong Woo Choi1, Jae-Hyun Park4, Jong Jin Choi1, Seok-Won Kim5, Jinah Jang6, Dong-Woo Cho5, Hyung-Min Chung1, Sung-Hwan Moon1,7,*, Kiwon Ban2,* & Hun-Jun Park3,4,8,*
1 Department of Medicine, Konkuk University School of Medicine, Seoul 05029, Republic of Korea. 2 Department of Biomedical Sciences, City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong SAR. 3 Department of Medical Life Science, College of Medicine, The Catholic University of Korea, 222 Banpo-daero, Seocho-gu, Seoul 137701, Republic of Korea. 4 Division of Cardiology, Department of Internal Medicine, Seoul St. Mary’s Hospital, The Catholic University of Korea, 222 Banpo-daero, Seocho-gu, Seoul 137701, Republic of Korea. 5 Department of Mechanical Engineering, Pohang University of Science and Technology, 77 Cheongam-ro, Hyogok-dong, Nam-gu, Pohang 37673, Republic of Korea. 6 Department of Creative IT Engineering and School of Interdisciplinary Bioscience and Bioengineering, Pohang University of Science and Technology, 77 Cheongam-ro, Hyogok-dong, Nam-gu, Pohang 37673, Republic of Korea. 7 Research Institute, T&R Biofab Co. Ltd, 237, Siheung, Republic of Korea. 8 Cell Death Disease Research Center, College of Medicine, The Catholic University of Korea, 222 Banpo-daero, Seocho-gu, Seoul 137701, Republic of Korea. 9 These authors contributed equally: Soon-Jung Park, Ri Youn Kim, Bong-Woo Park, Sunghun Lee.
*Correspondence and requests for materials should be addressed to S.-H.M. or to K.B. or to H.-J.P.
Abstract
Since both myocardium and vasculature in the heart are excessively damaged following myocardial infarction (MI), therapeutic strategies for treating MI hearts should concurrently target both so as to achieve true cardiac repair. Here we demonstrate a concomitant method that exploits the advantages of cardiomyocytes derived from human induced pluripotent stem cells (hiPSC-CMs) and human mesenchymal stem cell-loaded patch (hMSC-PA) to amplify cardiac repair in a rat MI model. Epicardially implanted hMSC-PA provide a complimentary microenvironment which enhances vascular regeneration through prolonged secretion of paracrine factors, but more importantly it significantly improves the retention and engraftment of intramyocardially injected hiPSC-CMs which ultimately restore the cardiac function. Notably, the majority of injected hiPSC-CMs display adult CMs like morphology suggesting that the secretomic milieu of hMSC-PA constitutes pleiotropic effects in vivo. We provide compelling evidence that this dual approach can be a promising means to enhance cardiac repair on MI hearts.
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